TAK1 is a ubiquitin-dependent kinase of MKK and IKK (Q24291454)

Mitogen-activated protein kinase kinase kinase 7

GOA release 2020-03-11

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positive regulation of protein kinase activity

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

C Wang

1

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L Deng

2

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M Hong

3

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G R Akkaraju

4

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J Inoue

5

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Z J Chen

TRAF6 is a signal transducer for interleukin-1

6

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language of work or name

English

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publication date

19 July 2001

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published in

Nature

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volume

412

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page(s)

346-51

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issue

6844

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cites work

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7 January 2021

Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region

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7 January 2021

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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7 January 2021

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

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7 January 2021

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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7 January 2021

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

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7 January 2021

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

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7 January 2021

Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity.

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7 January 2021

The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

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7 January 2021

IRAK: a kinase associated with the interleukin-1 receptor

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7 January 2021

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

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7 January 2021

Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta

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7 January 2021

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7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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7 January 2021

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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7 January 2021

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

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7 January 2021

Signal transduction by the JNK group of MAP kinases

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7 January 2021

Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates

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7 January 2021

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

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7 January 2021

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

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7 January 2021

Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice.

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7 January 2021

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

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7 January 2021

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

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7 January 2021