Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs (Q24318701)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

G protein-coupled receptor

8 February 2020

main subject

cell biology

0 references

0 references

F2R like trypsin receptor 1

1 reference

negative regulation of JNK cascade

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Margaret R Cunningham

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Laurence Cadalbert

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Robin Plevin

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1

Kathryn McIntosh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

John Lockhart

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Gary Boyd

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

W R Ferrell

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

language of work or name

English

0 references

publication date

23 September 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

number of pages

9

1 reference

inferred from page(s)

published in

Cellular Signalling

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

265-273

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity

8 February 2020

cites work

1 reference

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Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices

19 March 2017

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Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes

19 March 2017

1 reference

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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

19 March 2017

1 reference

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

19 March 2017

1 reference

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Signal transduction by the JNK group of MAP kinases

19 March 2017

1 reference

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Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1

19 March 2017

1 reference

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The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

19 March 2017

1 reference

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TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

19 March 2017

1 reference

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

19 March 2017

1 reference

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Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responses in vitro and in vivo

7 April 2017

1 reference

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G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes

27 September 2017

1 reference

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EGF receptor transactivation and MAP kinase mediate proteinase-activated receptor-2-induced chloride secretion in intestinal epithelial cells

27 September 2017

1 reference

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PAR-2 activation and LPS synergistically enhance inflammatory signaling in airway epithelial cells by raising PAR expression level and interleukin-8 release

27 September 2017

1 reference

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Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2.

27 September 2017

1 reference

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Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization

27 September 2017

1 reference

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Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation.

27 September 2017

1 reference

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Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice

27 September 2017

1 reference

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PAR-2 activation in intestinal epithelial cells potentiates interleukin-1beta-induced chemokine secretion via MAP kinase signaling pathways.

27 September 2017

1 reference

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Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.

27 September 2017

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Physiology and pathophysiology of proteinase-activated receptors (PARs): proteinases as hormone-like signal messengers: PARs and more

27 September 2017

1 reference

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Potent and metabolically stable agonists for protease-activated receptor-2: evaluation of activity in multiple assay systems in vitro and in vivo

27 September 2017

1 reference

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Protein kinase C isozymes regulate proliferation and high cell density-mediated differentiation in HaCaT keratinocytes

27 September 2017

1 reference

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Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

27 September 2017

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The signaling adaptors and pathways activated by TNF superfamily

27 September 2017

1 reference

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Essential role for proteinase-activated receptor-2 in arthritis

27 September 2017

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Tryptase activates the mitogen-activated protein kinase/activator protein-1 pathway in human peripheral blood eosinophils, causing cytokine production and release

27 September 2017

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Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha

27 September 2017

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Proteinase-activated receptors.

27 September 2017

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Contribution of receptor/G protein signaling to cell growth and transformation.

27 September 2017

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Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart

27 September 2017

1 reference

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Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

27 September 2017

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Permanent cell line expressing human factor VIII-related antigen established by hybridization

27 September 2017

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The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor

27 September 2017

1 reference

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Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cells

27 September 2017

1 reference

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Protease-activated receptor-2 simultaneously directs beta-arrestin-1-dependent inhibition and Galphaq-dependent activation of phosphatidylinositol 3-kinase

30 May 2018

1 reference

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Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

30 May 2018

1 reference

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Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw.

30 May 2018

1 reference

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Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H- pyrrole-2,5-dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model

30 May 2018

1 reference

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Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling compl

30 May 2018

1 reference

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Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo

29 November 2018

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Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling

29 November 2018

1 reference

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Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling

29 November 2018

1 reference

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Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear.

29 November 2018

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Trypsin stimulates proteinase-activated receptor-2-dependent and -independent activation of mitogen-activated protein kinases

29 November 2018

1 reference

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Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19781631

12 December 2020

inferred from PubMed ID database lookup

Protease-Activated Receptor-2-Mediated Proliferation and Collagen Production of Rat Pancreatic Stellate Cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19781631

12 December 2020

inferred from PubMed ID database lookup

A protective role for protease-activated receptors in the airways

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19781631

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.CELLSIG.2009.09.028

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781631%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference