Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta (Q24319688)

Axin 1

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glycogen synthase kinase 3 beta

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negative regulation of canonical Wnt signaling pathway

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author name string

M J Hart

1

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R de los Santos

2

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I N Albert

3

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B Rubinfeld

4

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P Polakis

Identification and characterization of the familial adenomatous polyposis coli gene

5

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language of work or name

English

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publication date

7 May 1998

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published in

Current Biology

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volume

8

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issue

10

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page(s)

573-81

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cites work

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Lessons from hereditary colorectal cancer

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Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients

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APC mutations occur early during colorectal tumorigenesis

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The adenomatous polyposis coli gene and human cancers

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Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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Stabilization of beta-catenin by genetic defects in melanoma cell lines

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Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

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A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells

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Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

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Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes

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Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

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The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

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Components of wingless signalling in Drosophila.

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Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.

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Wnt signaling: a common theme in animal development

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The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

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Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

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Mutations in the APC gene and their implications for protein structure and function

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Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

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Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis

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Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos

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Association of the APC gene product with beta-catenin

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