Axin 1 (Q21109410)

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mammalian protein found in Homo sapiens
  • hAxin
  • axis inhibition protein 1
  • AXIN1
  • fused, mouse, homolog of
  • protein phosphatase 1, regulatory subunit 49
  • axis inhibitor 1
  • axin-1
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Language Label Description Also known as
English
Axin 1
mammalian protein found in Homo sapiens
  • hAxin
  • axis inhibition protein 1
  • AXIN1
  • fused, mouse, homolog of
  • protein phosphatase 1, regulatory subunit 49
  • axis inhibitor 1
  • axin-1

Statements

molecular function
protein binding
determination method
IPI
42 references
retrieved
9 May 2019
stated in
Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis
GOA
curator
UniProt
UniProt protein ID
O15169
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC
GOA
curator
UniProt
UniProt protein ID
O15169
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β
GOA
curator
UniProt
UniProt protein ID
O15169
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways
GOA
curator
UniProt
UniProt protein ID
O15169
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
GOA
curator
UniProt
UniProt protein ID
O15169
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Axin localizes to the centrosome and is involved in microtubule nucleation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Kaiso is a bimodal modulator for Wnt/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
retrieved
9 May 2019
stated in
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169
determination method
IPI
cell component
biological process

Identifiers

 
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