In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6 (Q24319719)

Ryanodine receptor 2

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FKBP prolyl isomerase 1A

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positive regulation of ATPase-coupled calcium transmembrane transporter activity

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author name string

Christopher H George

1

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Rina Sorathia

2

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Benedicte M A Bertrand

3

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F Anthony Lai

FKBP binding characteristics of cardiac microsomes from diverse vertebrates

4

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language of work or name

English

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publication date

1 March 2003

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published in

Biochemical Journal

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volume

370

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issue

Pt 2

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page(s)

579-89

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cites work

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Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor

19 March 2017

1 reference

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PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

19 March 2017

1 reference

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The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis

19 March 2017

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A new generation of Ca2+ indicators with greatly improved fluorescence properties

19 March 2017

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Postulated role of inter-domain interaction within the ryanodine receptor in Ca(2+) channel regulation

19 March 2017

1 reference

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Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia

19 March 2017

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Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia

19 March 2017

1 reference

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FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain

19 March 2017

1 reference

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Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2.

19 March 2017

1 reference

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Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

19 March 2017

1 reference

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Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux

19 March 2017

1 reference

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Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene

19 March 2017

1 reference

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Regulation of ryanodine receptors via macromolecular complexes: a novel role for leucine/isoleucine zippers

19 March 2017

1 reference

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Light at the end of the Ca(2+)-release channel tunnel: structures and mechanisms involved in ion translocation in ryanodine receptor channels

27 September 2017

1 reference

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Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate.

27 September 2017

1 reference

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Divergent functional properties of ryanodine receptor types 1 and 3 expressed in a myogenic cell line

27 September 2017

1 reference

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ATP-induced activation of expressed RyR3 at low free calcium.

27 September 2017

1 reference

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Three-dimensional location of the imperatoxin A binding site on the ryanodine receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

Expression and functional characterization of the cardiac muscle ryanodine receptor Ca(2+) release channel in Chinese hamster ovary cells

27 September 2017

1 reference

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Characterization of recombinant rabbit cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) with a novel [3H]ryanodine binding assay

27 September 2017

1 reference

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Functional consequences of mutations of conserved, polar amino acids in transmembrane sequences of the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum

27 September 2017

1 reference

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Cryoelectron microscopy resolves FK506-binding protein sites on the skeletal muscle ryanodine receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

Ryanodine receptor/Ca2+ release channels and their regulation by endogenous effectors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunits

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

Augmentation of SR Ca(2+) release by rapamycin and FK506 causes K(+)-channel activation and membrane hyperpolarization in bladder smooth muscle

27 September 2017

1 reference

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Neural actions of immunophilin ligands.

30 May 2018

1 reference

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Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release channels in mammalian tissues and cell lines

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

FKBP12 associates tightly with the skeletal muscle type 1 ryanodine receptor, but not with other intracellular calcium release channels.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

2-aminoethoxydiphenyl borate reveals heterogeneity in receptor-activated Ca(2+) discharge and store-operated Ca(2+) influx

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

Protein-protein interactions in intracellular Ca2+-release channel function.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

Generation and characterization of mutant mice lacking ryanodine receptor type 3.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223191

Altered interaction of FKBP12.6 with ryanodine receptor as a cause of abnormal Ca(2+) release in heart failure

29 November 2018

1 reference

12 December 2020

The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions

1 reference

12 December 2020

Intrinsic lattice formation by the ryanodine receptor calcium-release channel

1 reference

12 December 2020

Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure

1 reference

12 December 2020

Isolation of sarcoplasmic reticulum fractions referable to longitudinal tubules and junctional terminal cisternae from rabbit skeletal muscle

1 reference

12 December 2020

The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum

1 reference

12 December 2020

Chlorocresol: an activator of ryanodine receptor-mediated Ca2+ release

1 reference

12 December 2020

The ryanodine receptor from canine heart sarcoplasmic reticulum is associated with a novel FK-506 binding protein

1 reference

12 December 2020

Effects of rapamycin on ryanodine receptor/Ca(2+)-release channels from cardiac muscle

1 reference

12 December 2020

Selective binding of FKBP12.6 by the cardiac ryanodine receptor

1 reference

12 December 2020

Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors

1 reference

12 December 2020

Different interactions of cardiac and skeletal muscle ryanodine receptors with FK-506 binding protein isoforms

1 reference

12 December 2020

Locations of calmodulin and FK506-binding protein on the three-dimensional architecture of the skeletal muscle ryanodine receptor

1 reference

12 December 2020

Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation

1 reference

12 December 2020

Modulation of intracellular Ca2+ levels in the heart by sorcin and FKBP12, two accessory proteins of ryanodine receptors

1 reference

12 December 2020

Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

1 reference

12 December 2020

Three amino acid residues determine selective binding of FK506-binding protein 12.6 to the cardiac ryanodine receptor

1 reference

12 December 2020