Ryanodine receptor 2 (Q3415811)

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mammalian protein found in Homo sapiens
  • cardiac muscle ryanodine receptor-calcium release channel
  • cardiac-type ryanodine receptor
  • ryanodine receptor 2
  • kidney-type ryanodine receptor
  • ryanodine receptor 2 (cardiac)
  • type 2 ryanodine receptor
  • Cardiac muscle ryanodine receptor
  • RYR2
  • islet-type ryanodine receptor
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Language Label Description Also known as
English
Ryanodine receptor 2
mammalian protein found in Homo sapiens
  • cardiac muscle ryanodine receptor-calcium release channel
  • cardiac-type ryanodine receptor
  • ryanodine receptor 2
  • kidney-type ryanodine receptor
  • ryanodine receptor 2 (cardiac)
  • type 2 ryanodine receptor
  • Cardiac muscle ryanodine receptor
  • RYR2
  • islet-type ryanodine receptor

Statements

part of
molecular function
protein binding
determination method
IPI
7 references
retrieved
8 April 2019
stated in
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
GOA
curator
UniProt
UniProt protein ID
Q92736
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IPI
retrieved
8 April 2019
stated in
Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias
GOA
curator
UniProt
UniProt protein ID
Q92736
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IPI
retrieved
8 April 2019
stated in
In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IPI
retrieved
8 April 2019
stated in
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IPI
retrieved
8 April 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IPI
retrieved
8 April 2019
stated in
FKBP binding characteristics of cardiac microsomes from diverse vertebrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IPI
retrieved
8 April 2019
stated in
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IPI
calmodulin binding
determination method
IDA
IEA
IMP
IPI
ISS
8 references
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
ISS
retrieved
8 April 2019
stated in
Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IPI
retrieved
8 April 2019
stated in
Ca(2+)-calmodulin can activate and inactivate cardiac ryanodine receptors
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q92736
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IEA
retrieved
8 April 2019
stated in
Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease
GOA
curator
UniProt
UniProt protein ID
Q92736
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IDA
retrieved
8 April 2019
stated in
FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel
GOA
curator
UniProt
UniProt protein ID
Q92736
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IDA
retrieved
8 April 2019
stated in
Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks
GOA
curator
UniProt
UniProt protein ID
Q92736
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736
determination method
IDA
cell component
biological process
has part(s)

Identifiers

 
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