Expression and functional analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 isozymes (Q24320062)

GOA release 2020-03-11

aromatase activity

1 reference

GOA release 2020-03-11

author name string

Wei-Yan Zhang

1

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You-Bin Tu

2

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Robert L Haining

3

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Ai-Ming Yu

Drug Metabolism and Disposition

4

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language of work or name

English

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publication date

January 2009

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published in

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volume

37

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issue

1

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page(s)

1-4

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cites work

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Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17

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A silent mutation (2939G>A, exon 6; CYP2D6*59) leading to impaired expression and function of CYP2D6.

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Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

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Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

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Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelic isoforms

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29 November 2018

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Frequency of the frame-shifting CYP2D7 138delT polymorphism in a large, ethnically diverse sample population

29 November 2018

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New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes

29 November 2018

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CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status

29 November 2018

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CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?

29 November 2018

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Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase

29 November 2018

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Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

29 November 2018

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Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6.

29 November 2018

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Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

29 November 2018

1 reference

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A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18838503

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18838503

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/DMD.108.023663

1 reference

1 reference

1 reference

PubMed publication ID

18838503

1 reference