The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation (Q24322589)

William J McKinstry

11

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Hayley S. Ramshaw

Hayley Ramshaw

7

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Angel F. Lopez

Angel F Lopez

12

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Michael W Parker

Michael W Parker

13

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author name string

Guido Hansen

1

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Timothy R Hercus

2

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Barbara J McClure

3

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Frank C Stomski

4

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Mara Dottore

5

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Jason Powell

6

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Yibin Xu

9

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Mark Guthridge

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation

10

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language of work or name

English

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publication date

8 August 2008

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published in

Cell

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volume

134

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issue

3

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page(s)

496-507

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cites work

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Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF

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Refined crystal structure and mutagenesis of human granulocyte-macrophage colony-stimulating factor

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Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors

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Roles of the cytoplasmic domains of the alpha and beta subunits of human granulocyte-macrophage colony-stimulating factor receptor.

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Cell signaling by receptor tyrosine kinases

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Jak2 is essential for signaling through a variety of cytokine receptors

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Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration

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Dendritic cells: specialized and regulated antigen processing machines

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Co-expression of granulocyte-macrophage colony-stimulating factor with antigen enhances humoral and tumor immunity after DNA vaccination

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A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all thr

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A dominant negative granulocyte-macrophage colony-stimulating factor receptor alpha chain reveals the multimeric structure of the receptor complex

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Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three recepto

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A cell type-specific constitutive point mutant of the common beta-subunit of the human granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5 receptors requires the GM-CSF receptor alpha-subunit for activation

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Crucial role of the residue R280 at the F'-G' loop of the human granulocyte/macrophage colony-stimulating factor receptor alpha chain for ligand recognition

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JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region

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Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease

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