Cell signaling by receptor tyrosine kinases (Q27860474)

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

Europe PubMed Central

title

Cell signaling by receptor tyrosine kinases (English)

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author name string

J Schlessinger

series ordinal

1

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language of work or name

English

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publication date

13 October 2000

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published in

Cell

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volume

103

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issue

2

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page(s)

211-25

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Folding and stability of the Z and S(iiyama) genetic variants of human alpha1-antitrypsin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Ras and Rho GTPases: a family reunion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

SHIP modulates immune receptor responses by regulating membrane association of Btk.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Structure and function of sphingolipid- and cholesterol-rich membrane rafts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Control of EGF receptor signalling: lessons from fruitflies.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

PIP2 and PIP3: complex roles at the cell surface

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Signal transduction by the JNK group of MAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Lipid microdomains in cell surface membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

SOCS-3 is an insulin-induced negative regulator of insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Extracellular domains drive homo- but not hetero-dimerization of erbB receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Phosphoinositide binding domains: embracing 3-phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Secondary dimerization between members of the epidermal growth factor receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Organization and regulation of mitogen-activated protein kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Clustering membrane proteins: It's all coming together with the PSD-95/SAP90 protein family

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Dimerization of cell surface receptors in signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Twenty proteins containing a C-terminal SOCS box form five structural classes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Proxy activation of protein ErbB2 by heterologous ligands implies a heterotetrameric mode of receptor tyrosine kinase interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Autoregulatory mechanisms in protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Signaling--2000 and beyond

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Cytokine receptor signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Receptor signaling: when dimerization is not enough

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Signaling networks: the origins of cellular multitasking

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Src family kinases are required for integrin but not PDGFR signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Structural basis for cytokine hormone-receptor recognition and receptor activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Modular peptide recognition domains in eukaryotic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Regulation of signal transduction and signal diversity by receptor oligomerization

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Two EGF molecules contribute additively to stabilization of the EGFR dimer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

The riddle of MAP kinase signaling specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

The PTB Domain: The Name Doesn't Say It All

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

FGF signaling in skeletal development.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

TGFbeta signaling in growth control, cancer, and heritable disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

The ErbB signaling network: receptor heterodimerization in development and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Protein modules and signalling networks

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

1 reference

7 January 2021

Signaling through scaffold, anchoring, and adaptor proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Structural basis for FGF receptor dimerization and activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

The role of phosphoinositide 3-kinase lipid products in cell function

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Signal transduction by allosteric receptor oligomerization

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

SH2/SH3 signaling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Functional rafts in cell membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Translocation and reversible localization of signaling proteins: a dynamic future for signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Cellular functions regulated by Src family kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Cellular signaling: pivoting around PDK-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Bivalence of EGF-like ligands drives the ErbB signaling network

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Signal transduction by receptors with tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Signalling through the insulin receptor and the insulin-like growth factor-I receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Alternately spliced NH2-terminal immunoglobulin-like Loop I in the ectodomain of the fibroblast growth factor (FGF) receptor 1 lowers affinity for both heparin and FGF-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900114-8

7 January 2021

10.1016/S0092-8674(00)00114-8

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

500104

500104

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference