Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels (Q24322711)

GOA release 2020-03-11

mRNA 3'-UTR binding

1 reference

Pumilio RNA-binding family member 1

GOA release 2020-03-11

1 reference

Vincenzo Alessandro Gennarino

GOA release 2020-03-11

1 reference

Ravi K Singh

2

0 references

Vincenzo A Gennarino

1

0 references

Harry T. Orr

Harry T Orr

12

0 references

Huda Zoghbi

Huda Y Zoghbi

14

0 references

Antonia De Maio

Antonia De Maio

4

0 references

author name string

Joshua J White

3

0 references

Kihoon Han

5

0 references

Ji-Yoen Kim

6

0 references

Paymaan Jafar-Nejad

7

0 references

Alberto di Ronza

8

0 references

Hyojin Kang

9

0 references

Layal S Sayegh

10

0 references

Thomas A Cooper

11

0 references

Roy V Sillitoe

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease

13

0 references

language of work or name

English

0 references

publication date

12 March 2015

0 references

published in

Cell

0 references

volume

160

0 references

issue

6

0 references

page(s)

1087-98

0 references

cites work

1 reference

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Pumilio facilitates miRNA regulation of the E2F3 oncogene

19 March 2017

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HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis

19 March 2017

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A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility

19 March 2017

1 reference

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UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs

19 March 2017

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HuR recruits let-7/RISC to repress c-Myc expression

19 March 2017

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MicroRNAs: target recognition and regulatory functions

19 March 2017

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Pathogenic mechanisms of a polyglutamine-mediated neurodegenerative disease, spinocerebellar ataxia type 1

19 March 2017

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Most mammalian mRNAs are conserved targets of microRNAs

19 March 2017

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Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system

19 March 2017

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miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis

19 March 2017

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19 March 2017

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

19 March 2017

1 reference

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Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals

19 March 2017

1 reference

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Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information

19 March 2017

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Modular recognition of RNA by a human pumilio-homology domain

19 March 2017

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alpha-Synuclein locus triplication causes Parkinson's disease

19 March 2017

1 reference

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A new mathematical model for relative quantification in real-time RT-PCR

19 March 2017

1 reference

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PUF proteins bind Pop2p to regulate messenger RNAs

19 March 2017

1 reference

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

19 March 2017

1 reference

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Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis

19 March 2017

1 reference

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RNA-binding proteins in human genetic disease

19 March 2017

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Relief of microRNA-mediated translational repression in human cells subjected to stress

24 March 2017

19 March 2017

1 reference

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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

19 March 2017

1 reference

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

19 March 2017

1 reference

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Protein aggregation and neurodegenerative disease

19 March 2017

2 references

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19 March 2017

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Genetic exploration of the exit from self-renewal using haploid embryonic stem cells

7 April 2017

1 reference

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

19 March 2017

1 reference

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A PUF family portrait: 3'UTR regulation as a way of life

7 April 2017

1 reference

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Landscape and variation of RNA secondary structure across the human transcriptome

26 May 2017

1 reference

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RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

27 September 2017

1 reference

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The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.

27 September 2017

1 reference

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HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA.

27 September 2017

1 reference

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Identification of microRNA-regulated gene networks by expression analysis of target genes

27 September 2017

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A conserved PUF-Ago-eEF1A complex attenuates translation elongation.

27 September 2017

1 reference

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HOCTAR database: a unique resource for microRNA target prediction

27 September 2017

1 reference

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27 September 2017

1 reference

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Predicting in vivo binding sites of RNA-binding proteins using mRNA secondary structure

27 September 2017

1 reference

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FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline

27 September 2017

1 reference

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Memory efficient folding algorithms for circular RNA secondary structures

27 September 2017

1 reference

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The PUF family of RNA-binding proteins: does evolutionarily conserved structure equal conserved function?

27 September 2017

1 reference

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Unfolding the role of protein misfolding in neurodegenerative diseases

27 September 2017

1 reference

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Glutamine repeats and neurodegeneration

27 September 2017

1 reference

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Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.

27 September 2017

1 reference

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Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

27 September 2017

1 reference

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Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes

30 May 2018

1 reference

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Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

29 November 2018

1 reference

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A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.

29 November 2018

1 reference

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Identification of genes that modify ataxin-1-induced neurodegeneration.

29 November 2018

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

29 November 2018

1 reference

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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

29 November 2018

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Cloning and developmental expression analysis of the murine homolog of the spinocerebellar ataxia type 1 gene (Sca1).

29 November 2018

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Identification and characterization of the gene causing type 1 spinocerebellar ataxia

29 November 2018

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Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

29 November 2018

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12 December 2020

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SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

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12 December 2020

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