Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide (Q28131750)

Nature Reviews Molecular Cell Biology

Europe PubMed Central

title

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide (English)

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1

Christian Haass

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Dennis J. Selkoe

series ordinal

2

object named as

Dennis J Selkoe

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language of work or name

English

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publication date

February 2007

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published in

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volume

8

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page(s)

101-12

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issue

2

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cites work

Genetics of Parkinson's disease

1 reference

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

31 March 2020

1 reference

Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases

31 March 2020

1 reference

Alpha-synuclein in Lewy bodies

31 March 2020

1 reference

Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

31 March 2020

1 reference

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

31 March 2020

1 reference

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

31 March 2020

1 reference

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

31 March 2020

1 reference

Amyloid plaque core protein in Alzheimer disease and Down syndrome

31 March 2020

1 reference

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

31 March 2020

1 reference

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

31 March 2020

1 reference

One of the antigenic determinants of paired helical filaments is related to tau protein.

31 March 2020

1 reference

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

31 March 2020

1 reference

Presenile dementia and Alzheimer's disease in mongolism.

31 March 2020

1 reference

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

31 March 2020

1 reference

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

31 March 2020

1 reference

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

31 March 2020

1 reference

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

31 March 2020

1 reference

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

31 March 2020

1 reference

The molecular pathology of Alzheimer's disease

31 March 2020

1 reference

Alzheimer's disease: the amyloid cascade hypothesis

31 March 2020

1 reference

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

31 March 2020

1 reference

Amyloid beta-peptide is produced by cultured cells during normal metabolism

31 March 2020

1 reference

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

31 March 2020

1 reference

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

31 March 2020

1 reference

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

31 March 2020

1 reference

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

31 March 2020

1 reference

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

31 March 2020

1 reference

Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

31 March 2020

1 reference

Notch signaling: from the outside in

31 March 2020

1 reference

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

31 March 2020

1 reference

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

31 March 2020

1 reference

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

31 March 2020

1 reference

The role of presenilin cofactors in the gamma-secretase complex

31 March 2020

1 reference

Reconstitution of gamma-secretase activity

31 March 2020

1 reference

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

31 March 2020

1 reference

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

31 March 2020

1 reference

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

31 March 2020

1 reference

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

31 March 2020

1 reference

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

31 March 2020

1 reference

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

31 March 2020

1 reference

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

31 March 2020

1 reference

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

31 March 2020

1 reference

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.

31 March 2020

1 reference

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

31 March 2020

1 reference

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

31 March 2020

1 reference

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

31 March 2020

1 reference

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.

31 March 2020

1 reference

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

31 March 2020

1 reference

Structural and kinetic features of amyloid beta-protein fibrillogenesis.

31 March 2020

1 reference

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

31 March 2020

1 reference

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

31 March 2020

1 reference

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

31 March 2020

1 reference

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

31 March 2020

1 reference

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

31 March 2020

1 reference

Neurodegenerative disease: amyloid pores from pathogenic mutations.

31 March 2020

1 reference

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

31 March 2020

1 reference

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

31 March 2020

1 reference

A specific amyloid-beta protein assembly in the brain impairs memory

31 March 2020

1 reference

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

31 March 2020

1 reference

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

31 March 2020

1 reference

Presence of sodium dodecyl sulfate-stable amyloid beta-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation

31 March 2020

1 reference

Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging

31 March 2020

1 reference

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

31 March 2020

1 reference

Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.

31 March 2020

1 reference

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

31 March 2020

1 reference

APP processing and synaptic function

31 March 2020

1 reference

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

31 March 2020

1 reference

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

31 March 2020

1 reference

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

31 March 2020

1 reference

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

31 March 2020

1 reference

Regulation of NMDA receptor trafficking by amyloid-beta

31 March 2020

1 reference

Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

31 March 2020

1 reference

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

31 March 2020

1 reference

Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

31 March 2020

1 reference

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

31 March 2020

1 reference

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

31 March 2020

1 reference

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

31 March 2020

1 reference

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

31 March 2020

1 reference

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

31 March 2020

1 reference

Spontaneous formation of annular structures observed in molecular dynamics simulations of polyglutamine peptides

31 March 2020

1 reference

ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures

31 March 2020

1 reference

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

31 March 2020

1 reference

A nucleated assembly mechanism of Alzheimer paired helical filaments

31 March 2020

1 reference

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

31 March 2020

1 reference

Control of peripheral nerve myelination by the beta-secretase BACE1

31 March 2020

1 reference

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

31 March 2020

1 reference

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

31 March 2020

1 reference

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

31 March 2020

1 reference

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

31 March 2020

1 reference

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

31 March 2020

1 reference

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

31 March 2020

1 reference

Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis

31 March 2020

1 reference

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

31 March 2020

1 reference

Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.

31 March 2020

1 reference

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

31 March 2020

1 reference

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

31 March 2020

1 reference

Immunotherapy for Alzheimer's disease

31 March 2020

1 reference

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

31 March 2020

1 reference

Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

31 March 2020

1 reference

Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide

31 March 2020

1 reference

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

31 March 2020

1 reference

The plasmin system is induced by and degrades amyloid-beta aggregates

31 March 2020

1 reference

Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease

31 March 2020

1 reference

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

31 March 2020

1 reference

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

31 March 2020

1 reference

Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

31 March 2020

1 reference

Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth

31 March 2020

1 reference

Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity.

31 March 2020

1 reference

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

31 March 2020

1 reference

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

31 March 2020

1 reference

Presenilin-dependent gamma-secretase activity modulates thymocyte development

31 March 2020

1 reference

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

31 March 2020

1 reference

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

31 March 2020

1 reference

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

31 March 2020

1 reference

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

31 March 2020

1 reference

Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

31 March 2020

1 reference

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

31 March 2020

1 reference

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

31 March 2020

1 reference

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

31 March 2020

1 reference

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

31 March 2020

1 reference

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

31 March 2020

1 reference

alpha-Synuclein locus triplication causes Parkinson's disease

31 March 2020

1 reference

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

31 March 2020

1 reference

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

31 March 2020

1 reference

Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM2101

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

272544

1027439624

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272544

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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