Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88 (Q24328759)

heparan sulfate proteoglycan metabolic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Md Motarab Hossain

1

0 references

Tomomi Hosono-Fukao

2

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Renhong Tang

3

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Noriko Sugaya

4

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Toin H van Kuppevelt

5

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Guido J Jenniskens

6

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Koji Kimata

7

0 references

Steven D Rosen

8

0 references

Kenji Uchimura

Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain

9

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language of work or name

English

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publication date

February 2010

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published in

Glycobiology

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volume

20

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issue

2

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page(s)

175-86

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cites work

1 reference

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Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

19 March 2017

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Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma

19 March 2017

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Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival

19 March 2017

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Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2

19 March 2017

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Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity

19 March 2017

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HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.

19 March 2017

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Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer

19 March 2017

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Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2

19 March 2017

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Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer

19 March 2017

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QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling

19 March 2017

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Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

19 March 2017

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Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate

19 March 2017

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Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays

19 March 2017

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Animal cell mutants defective in glycosaminoglycan biosynthesis

19 March 2017

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SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation

19 March 2017

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Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality

19 March 2017

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The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases

19 March 2017

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Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme

19 March 2017

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Exosomes: composition, biogenesis and function

19 March 2017

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Heparan sulphate proteoglycans fine-tune mammalian physiology

7 April 2017

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Order out of chaos: assembly of ligand binding sites in heparan sulfate

7 April 2017

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Functions of cell surface heparan sulfate proteoglycans

7 April 2017

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Quail Sulf1 function requires asparagine-linked glycosylation

7 April 2017

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Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells

27 September 2017

1 reference

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Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

The role of heparan sulphate in inflammation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Interactions between heparan sulfate and proteins: the concept of specificity

27 September 2017

1 reference

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Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Functions of heparan sulfate proteoglycans in cell signaling during development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Sulfation pattern in glycosaminoglycan: does it have a code?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Phosphomannopentaose sulfate (PI-88): heparan sulfate mimetic with clinical potential in multiple vascular pathologies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approaches

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Heparan sulfate: growth control with a restricted sequence menu

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Molecular diversity of heparan sulfate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Heparan sulfate heterogeneity in skeletal muscle basal lamina: demonstration by phage display-derived antibodies.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidney

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Developmental changes in heparan sulfate expression: in situ detection with mAbs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Extracellular regulation of developmental cell signaling by XtSulf1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Measuring the activities of the Sulfs: two novel heparin/heparan sulfate endosulfatases.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Novel heparan sulfate structures revealed by monoclonal antibodies

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Spatiotemporal distribution of heparan sulfate epitopes during myogenesis and synaptogenesis: a study in developing mouse intercostal muscle

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Large, tissue-regulated domain diversity of heparan sulfates demonstrated by phage display antibodies

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800247

Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19822709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19822709