Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer (Q24550887)

5

object named as

Mikala Egeblad

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author name string

Megumi Morimoto-Tomita

1

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Kenji Uchimura

2

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Annette Bistrup

3

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David H Lum

4

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Nancy Boudreau

6

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Steven D Rosen

HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.

8

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language of work or name

English

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publication date

November 2005

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published in

Neoplasia

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volume

7

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issue

11

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page(s)

1001-10

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cites work

1 reference

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Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression

24 March 2017

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QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling

24 March 2017

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Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

24 March 2017

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Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

24 March 2017

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Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis

24 March 2017

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Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities

24 March 2017

1 reference

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The Homeobox Transcription Factor Hox D3 Promotes Integrin α5β1 Expression and Function during Angiogenesis

24 March 2017

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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

24 March 2017

1 reference

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Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Identification of a novel nonlysosomal sulphatase expressed in the floor plate, choroid plexus and cartilage

24 March 2017

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Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

24 March 2017

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Order out of chaos: assembly of ligand binding sites in heparan sulfate

24 March 2017

1 reference

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Functions of cell surface heparan sulfate proteoglycans

7 April 2017

1 reference

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Requirement of vascular integrin alpha v beta 3 for angiogenesis

7 April 2017

1 reference

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Functions of heparan sulfate proteoglycans in cell signaling during development

7 April 2017

1 reference

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Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility

27 September 2017

1 reference

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Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and angiogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Tissue-wide expression profiling using cDNA subtraction and microarrays to identify tumor-specific genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Characterization of growth factor-binding structures in heparin/heparan sulfate using an octasaccharide library

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Roles of heparan-sulphate glycosaminoglycans in cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Heparan sulfate: growth control with a restricted sequence menu

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Molecular diversity of heparan sulfate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Defining the interleukin-8-binding domain of heparan sulfate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Structural modification of fibroblast growth factor-binding heparan sulfate at a determinative stage of neural development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

The sulfatase gene family

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Gene expression profiles in breast tumors regarding the presence or absence of estrogen and progesterone receptors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Distinctive expression patterns of heparan sulfate O-sulfotransferases and regional differences in heparan sulfate structure in chick limb buds.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Large, tissue-regulated domain diversity of heparan sulfates demonstrated by phage display antibodies

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Sequence analysis of heparan sulfate epitopes with graded affinities for fibroblast growth factors 1 and 2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1502017

Coordinated modulation of the fibroblast growth factor dual receptor mechanism during transformation from human colon adenoma to carcinoma

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16331886

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Heparanase as mediator of angiogenesis: mode of action

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16331886

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1593/NEO.05496

1 reference

780353

780353

1 reference

1 reference

1 reference