G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets (Q24336496)

GOA release 2020-03-11

blood coagulation

1 reference

Proceedings of the National Academy of Sciences of the United States of America

GOA release 2020-03-11

S Offermanns

1

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author name string

K L Laugwitz

series ordinal

2

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K Spicher

series ordinal

3

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G Schultz

series ordinal

4

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language of work or name

English

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publication date

18 January 1994

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published in

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volume

91

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issue

2

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page(s)

504-8

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cites work

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Binding characteristics of the new thromboxane A2/prostaglandin H2 receptor antagonist [3H]BAY U 3405 to washed human platelets and platelet membranes

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The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

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Platelet adenylate cyclase and phospholipase C are affected differentially by ADP-ribosylation. Effects on thrombin-mediated responses

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Evidence for two GTPases activated by thrombin in membranes of human platelets

30 May 2018

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Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs

30 May 2018

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Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni.

30 May 2018

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Tissue distribution of beta 1- and beta 2-subunits of regulatory guanine nucleotide-binding proteins.

30 May 2018

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Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.

30 May 2018

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Agonist-sensitive binding of a photoreactive GTP analog to a G-protein alpha-subunit in membranes of HL-60 cells

30 May 2018

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25 Identification of receptor-activated G proteins with photoreactive GTP analog, α-32PGTP azidoanilide

30 May 2018

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The role of GTP-binding proteins in platelet activation

30 May 2018

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Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones

30 May 2018

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Immunological identification of the alpha subunit of G13, a novel guanine nucleotide binding protein

30 May 2018

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Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C

30 May 2018

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Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1

30 May 2018

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Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family

30 May 2018

1 reference

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Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes

30 May 2018

1 reference

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Minimal sequence requirement of thrombin receptor agonist peptide

30 May 2018

1 reference

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Effects of gelsolin on human platelet cytosolic phosphoinositide-phospholipase C isozymes

30 May 2018

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Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells

30 May 2018

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Gz, a guanine nucleotide-binding protein with unique biochemical properties.

30 May 2018

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Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles

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12 December 2020

Na+/H+ exchange modulates Ca2+ mobilization in human platelets stimulated by ADP and the thromboxane mimetic U 46619

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The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems

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12 December 2020

Photoaffinity labeling of two rat liver plasma membrane proteins with [32P]gamma-azidoanilido GTP in response to vasopressin. Immunologic identification as alpha subunits of the Gq class of G proteins

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12 December 2020