Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity (Q24336875)

carbohydrate response element binding

GOA release 2020-03-11

1 reference

MLX interacting protein-like

GOA release 2020-03-11

1 reference

Journal of Biological Chemistry

GOA release 2020-03-11

author name string

Michael N Davies

series ordinal

1

0 references

Brennon L O'Callaghan

series ordinal

2

0 references

Howard C Towle

series ordinal

3

0 references

language of work or name

English

0 references

publication date

29 August 2008

0 references

published in

0 references

volume

283

0 references

issue

35

0 references

page(s)

24029-38

0 references

cites work

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Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein

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Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors

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Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

19 March 2017

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Identification of additional transcripts in the Williams-Beuren syndrome critical region

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c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells

19 March 2017

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c-Myc is required for the glucose-mediated induction of metabolic enzyme genes

19 March 2017

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A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver

19 March 2017

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Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

19 March 2017

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Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system

19 March 2017

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Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from Mondo conserved regions and essential trans-acting factor 14-3-3

27 September 2017

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Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liver

27 September 2017

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A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription

27 September 2017

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Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis

27 September 2017

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Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.

27 September 2017

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Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.

27 September 2017

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Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism

27 September 2017

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Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver

27 September 2017

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Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes

27 September 2017

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Nucleocytoplasmic shuttling of STAT transcription factors.

27 September 2017

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Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver

27 September 2017

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Glucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes

27 September 2017

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Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver.

27 September 2017

1 reference

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Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

27 September 2017

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Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Glucose regulation of gene transcription

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Carbohydrate regulation of the rat L-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Definition of the carbohydrate response element of the rat S14 gene. Context of the CACGTG motif determines the specificity of carbohydrate regulation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Cis-regulation of the L-type pyruvate kinase gene promoter by glucose, insulin and cyclic AMP

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Modulation of carbohydrate response element-binding protein gene expression in 3T3-L1 adipocytes and rat adipose tissue.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Transcriptional and post-transcriptional regulation of L-type pyruvate kinase gene expression in rat liver

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Nuclear export determines the cytokine sensitivity of STAT transcription factors

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527113

Effects of insulin and fructose on transcriptional and post-transcriptional regulation of malic enzyme synthesis in diabetic rat liver

29 November 2018

1 reference

PubMed

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inferred from PubMed ID database lookup

12 December 2020

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Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of fatty acid synthase in rat liver

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18591247

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18591247