Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR (Q24336882)

5

object named as

Harald Jüppner

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Murat Bastepe

4

object named as

Murat Bastepe

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author name string

Yutong Sun

1

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Jianyun Huang

2

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Yang Xiang

3

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J Jillian Zhang

7

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Xin-Yun Huang

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

8

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language of work or name

English

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publication date

10 January 2007

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published in

The EMBO Journal

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volume

26

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page(s)

53-64

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issue

1

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cites work

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The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

19 March 2017

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G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexes

19 March 2017

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Crystal structure of rhodopsin: A G protein-coupled receptor

19 March 2017

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The Hedgehog response network: sensors, switches, and routers

19 March 2017

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beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking

19 March 2017

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Homer: a protein that selectively binds metabotropic glutamate receptors

19 March 2017

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Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors

19 March 2017

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Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor

19 March 2017

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G proteins: transducers of receptor-generated signals

19 March 2017

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Cellular functions regulated by Src family kinases

7 April 2017

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Diversity of G proteins in signal transduction

7 April 2017

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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor

7 April 2017

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GPCR interacting proteins (GIP).

27 September 2017

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Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor

27 September 2017

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Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.

27 September 2017

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Receptor-mediated adenylyl cyclase activation through XLalpha(s), the extra-large variant of the stimulatory G protein alpha-subunit.

27 September 2017

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MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases

27 September 2017

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Csk, a critical link of g protein signals to actin cytoskeletal reorganization

27 September 2017

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Oligomerization of G-protein-coupled transmitter receptors.

27 September 2017

1 reference

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c-Src tyrosine kinase binds the beta 2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitization

27 September 2017

1 reference

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Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking.

27 September 2017

1 reference

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Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation

27 September 2017

1 reference

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Src tyrosine kinase is a novel direct effector of G proteins.

27 September 2017

1 reference

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beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf

27 September 2017

1 reference

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Temperature-sensitive Gbeta mutants discriminate between G protein-dependent and -independent signaling mediated by serpentine receptors

27 September 2017

1 reference

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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

27 September 2017

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beta2-adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists

27 September 2017

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Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases

27 September 2017

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Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors

27 September 2017

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Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts.

27 September 2017

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Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

27 September 2017

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Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.

30 May 2018

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Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor

30 May 2018

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Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine phosphorylation of p125 focal adhesion kinase

30 May 2018

1 reference

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Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782364

Selectivity of the .beta.-adrenergic receptor among Gs, Gi's, and Go: assay using recombinant .alpha. subunits in reconstituted phospholipid vesicles

30 May 2018

1 reference

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Not so strange bedfellows: G-protein-coupled receptors and Src family kinases

30 May 2018

1 reference

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Distinct roles for Src tyrosine kinase in beta2-adrenergic receptor signaling to MAPK and in receptor internalization

29 November 2018

1 reference

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Beta(2)-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for G(s)/G(i) switching.

29 November 2018

1 reference

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PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1.

29 November 2018

1 reference

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AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782364

Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles

29 November 2018

1 reference

12 December 2020

Seven helix cAMP receptors stimulate Ca2+ entry in the absence of functional G proteins in Dictyostelium

1 reference

12 December 2020

Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation

1 reference

12 December 2020

Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition

1 reference

12 December 2020

Angiotensin II Activates pp60 c- src in Vascular Smooth Muscle Cells

1 reference

12 December 2020

Nuclear signaling by endothelin-1 requires Src protein-tyrosine kinases

1 reference

12 December 2020

Angiotensin II Controls p21 Activity via pp60

1 reference

12 December 2020

Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells

1 reference

12 December 2020

Genetic evidence for a tyrosine kinase cascade preceding the mitogen-activated protein kinase cascade in vertebrate G protein signaling

1 reference

12 December 2020

G protein-coupled receptors control vascular smooth muscle cell proliferation via pp60c-src and p21ras

1 reference

12 December 2020

GATA-1 transactivates the WT1 hematopoietic specific enhancer

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601502

7 January 2021

inferred from DOI database lookup

c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 stimulation of macrophages

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601502

7 January 2021