The structure of human 5-lipoxygenase (Q24337021)

leukotriene biosynthetic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

6

A R Brash

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author name string

Nathaniel C Gilbert

1

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Sue G Bartlett

2

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Maria T Waight

3

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David B Neau

4

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William E Boeglin

5

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Marcia E Newcomer

Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein

7

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language of work or name

English

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publication date

14 January 2011

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published in

Science

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volume

331

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issue

6014

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page(s)

217-9

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

The 1.85 Å Structure of an 8 R -Lipoxygenase Suggests a General Model for Lipoxygenase Product Specificity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Conformational flexibility in mammalian 15S-lipoxygenase: Reinterpretation of the crystallographic data

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues

19 March 2017

1 reference

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Calcium binding to 5-lipoxygenase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

5-Lipoxygenase: mechanisms of regulation

19 March 2017

1 reference

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What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Improving protein crystal quality by selective removal of a Ca(2+)-dependent membrane-insertion loop

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Biosynthesis and metabolism of leukotrienes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Control of oxygenation in lipoxygenase and cyclooxygenase catalysis

27 September 2017

1 reference

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Solution structure of p53 core domain: structural basis for its instability

27 September 2017

1 reference

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Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Determinants of 5-lipoxygenase nuclear localization using green fluorescent protein/5-lipoxygenase fusion proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase.

27 September 2017

1 reference

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Investigation of the mechanism of non-turnover-dependent inactivation of purified human 5-lipoxygenase. Inactivation by H2O2 and inhibition by metal ions

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Kinetic Studies of Oxygen Reactivity in Soybean Lipoxygenase-1

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Amino acid differences in the deduced 5-lipoxygenase sequence of CAST atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Steric control of oxygenation regiochemistry in soybean lipoxygenase-1.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245680

Stabilization of purified human 5-lipoxygenase with glutathione peroxidase and superoxide dismutase

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21233389

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCIENCE.1197203

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1197203

1 reference

ADS bibcode

2011Sci...331..217G

0 references

1 reference

1 reference

PubMed publication ID

21233389

1 reference