Arachidonate 5-lipoxygenase (Q411791)

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mammalian protein found in Homo sapiens

• ALOX5
• arachidonate 5-lipoxygenase
• arachidonic acid 5-lipoxygenase
• LOX-5
• arachidonic 5-lipoxygenase delta-13 isoform
• uniprot:P09917
• arachidonic 5-lipoxygenase delta-p10 isoform
• arachidonic 5-lipoxygenase delta-10-13 isoform
• arachidonic 5-lipoxygenase alpha-10 isoform
• leukotriene A4 synthase
• ALOX5 protein, human

edit

Language	Label	Description	Also known as
English	Arachidonate 5-lipoxygenase	mammalian protein found in Homo sapiens	ALOX5 arachidonate 5-lipoxygenase arachidonic acid 5-lipoxygenase LOX-5 arachidonic 5-lipoxygenase delta-13 isoform uniprot:P09917 arachidonic 5-lipoxygenase delta-p10 isoform arachidonic 5-lipoxygenase delta-10-13 isoform arachidonic 5-lipoxygenase alpha-10 isoform leukotriene A4 synthase ALOX5 protein, human

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P09917

part of

Lipoxigenase, C-terminal domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P09917

PLAT/LH2 domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P09917

Lipoxygenase, mammalian

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P09917

Lipoxygenase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, iron binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

PLAT/LH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P09917

encoded by

ALOX5

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P09917

molecular function

iron ion binding

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

retrieved

8 April 2019

stated in

The structure of human 5-lipoxygenase

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IDA

arachidonate 5-lipoxygenase activity

determination method

IDA

IEA

TAS

4 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

retrieved

8 April 2019

stated in

Molecular cloning and amino acid sequence of human 5-lipoxygenase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

retrieved

8 April 2019

stated in

The structure of human 5-lipoxygenase

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IDA

dioxygenase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

metal ion binding

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

protein binding

determination method

IPI

8 references

retrieved

8 April 2019

stated in

Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IPI

retrieved

8 April 2019

stated in

Molecular cloning and functional characterization of mouse coactosin-like protein

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IPI

retrieved

8 April 2019

stated in

5-Lipoxygenase interacts with coactosin-like protein

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IPI

retrieved

8 April 2019

stated in

Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IPI

retrieved

8 April 2019

stated in

5-Lipoxygenase interacts with coactosin-like protein

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IPI

retrieved

8 April 2019

stated in

Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IPI

retrieved

8 April 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IPI

retrieved

8 April 2019

stated in

Widespread macromolecular interaction perturbations in human genetic disorders

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IPI

oxidoreductase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

cell component

cytoplasm

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

cytosol

determination method

IDA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

retrieved

8 April 2019

stated in

Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IDA

nuclear membrane

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

retrieved

8 April 2019

stated in

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IDA

membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

nuclear matrix

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

retrieved

8 April 2019

stated in

Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IDA

nuclear envelope lumen

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IDA

nucleus

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

extracellular region

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

extracellular space

determination method

IDA

1 reference

retrieved

17 October 2017

stated in

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09917&geneProductId=UniProtKB:P09917

determination method

IDA

nuclear envelope

determination method

IDA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

retrieved

8 April 2019

stated in

Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IDA

nucleoplasm

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IDA

secretory granule lumen

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

ficolin-1-rich granule lumen

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

extracellular space

determination method

HDA

1 reference

retrieved

8 April 2019

stated in

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

HDA

biological process

leukotriene metabolic process

determination method

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

retrieved

8 April 2019

stated in

Cloning of the cDNA for human 5-lipoxygenase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

leukotriene production involved in inflammatory response

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

leukotriene biosynthetic process

determination method

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

retrieved

8 April 2019

stated in

The structure of human 5-lipoxygenase

GOA

curator

UniProt

UniProt protein ID

P09917

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IDA

inflammatory response

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

IEA

lipoxin metabolic process

determination method

TAS

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09917&geneProductId=UniProtKB:P09917

determination method

TAS

lipoxygenase pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

neutrophil degranulation

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

cytokine-mediated signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

interleukin-18-mediated signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

long-chain fatty acid biosynthetic process

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

lipoxin biosynthetic process

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method

TAS

physically interacts with

zileuton

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5297

language of work or name

English

retrieved

17 August 2016

zileuton

object has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL93

Gene Atlas image

PBB GE ALOX5 204446 s at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P09917

1 reference

stated in

Identifiers.org

has part(s)

PLAT/LH2 domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P09917

Lipoxygenase, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P09917

Lipoxygenase, iron binding site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P09917

Lipoxygenase, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P09917

Identifiers

MeSH descriptor ID

C583212

subject named as

ALOX5 protein, human

0 references

RefSeq protein ID

NP_000689

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

240

NP_001243082

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

240

NP_001243083

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

240

NP_001307790

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

240

NP_001307791

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

240

XP_016871501

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

240

UniProt protein ID

P09917

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P09917

Ensembl protein ID

ENSP00000363512

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000363512

ENSP00000437634

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000437634

ENSP00000479958

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000479958

ENSP00000484468

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000484468

ENSP00000479452

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000479452

ENSP00000483803

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000483803

Freebase ID

/m/02qxl0z

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

90342290

0 references

PDB structure ID

3O8Y

1 reference

stated in

UniProt

UniProt protein ID

P09917

retrieved

4 August 2016

language of work or name

English

3V92

1 reference

stated in

UniProt

UniProt protein ID

P09917

retrieved

4 August 2016

language of work or name

English

3V98

1 reference

stated in

UniProt

UniProt protein ID

P09917

retrieved

4 August 2016

language of work or name

English

3V99

1 reference

stated in

UniProt

UniProt protein ID

P09917

retrieved

4 August 2016

language of work or name

English

UMLS CUI

C3711265

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q411791&oldid=2022901333"