Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor (Q24337508)

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7 February 2020

title

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor (English)

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7 February 2020

1

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7 February 2020

author name string

Selma El Messaoudi-Aubert

2

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7 February 2020

Sarah Elderkin

3

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7 February 2020

Kevin Hiom

4

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7 February 2020

Gordon Peters

5

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7 February 2020

language of work or name

English

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publication date

2 July 2010

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7 February 2020

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7 February 2020

volume

29

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page(s)

2553-2565

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issue

15

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Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus

7 February 2020

cites work

1 reference

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Defining the human deubiquitinating enzyme interaction landscape

19 March 2017

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USP11 stabilizes HPV-16E7 and further modulates the E7 biological activity

19 March 2017

1 reference

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

19 March 2017

1 reference

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Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus

19 March 2017

1 reference

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Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex

19 March 2017

1 reference

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Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b

19 March 2017

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Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase

19 March 2017

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Role of histone H2A ubiquitination in Polycomb silencing

19 March 2017

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BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage

19 March 2017

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A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

19 March 2017

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Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

19 March 2017

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Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

19 March 2017

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Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM

19 March 2017

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

19 March 2017

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A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

19 March 2017

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Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

19 March 2017

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Polycomb silencing mechanisms and the management of genomic programmes

19 March 2017

1 reference

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Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing

19 March 2017

1 reference

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A genomic and functional inventory of deubiquitinating enzymes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes

19 March 2017

1 reference

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GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7

19 March 2017

1 reference

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Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation

19 March 2017

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Tumour suppression: disruption of HAUSP gene stabilizes p53

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

A dynamic role of HAUSP in the p53-Mdm2 pathway

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Polycomb CBX7 has a unifying role in cellular lifespan

19 March 2017

1 reference

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor

19 March 2017

1 reference

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Suppression of induced pluripotent stem cell generation by the p53-p21 pathway

19 March 2017

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A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

7 April 2017

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The Ink4/Arf locus is a barrier for iPS cell reprogramming

7 April 2017

1 reference

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Linking the p53 tumour suppressor pathway to somatic cell reprogramming

7 April 2017

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Histone ubiquitination: triggering gene activity

7 April 2017

1 reference

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Cellular senescence: when bad things happen to good cells

7 April 2017

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Polycomb silencers control cell fate, development and cancer

7 April 2017

1 reference

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Senescence impairs successful reprogramming to pluripotent stem cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

The many faces of ubiquitinated histone H2A: insights from the DUBs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Cellular senescence in cancer and aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

INK4a/ARF: a multifunctional tumor suppressor locus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Contribution of p16(INK4a) to replicative senescence of human fibroblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.

27 September 2017

1 reference

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HAUSP is required for p53 destabilization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Stabilization of chromatin structure by PRC1, a Polycomb complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

Histone 2B can be modified by the attachment of ubiquitin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928679

The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP.

30 May 2018

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The power and the promise of oncogene-induced senescence markers.

21 January 2018

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A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMBOJ.2010.129

A Drosophila Polycomb group complex includes Zeste and dTAFII proteins.

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMBOJ.2010.129

Polycomb Group proteins: an evolutionary perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.129

Isolation of histones and nucleosome cores from mammalian cells

21 January 2018

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12 December 2020

The Polycomb Protein Ring1B Generates Self Atypical Mixed Ubiquitin Chains Required for Its In Vitro Histone H2A Ligase Activity

1 reference

12 December 2020

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1 reference

12 December 2020

The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)

1 reference

12 December 2020

Small but effective moves towards a greener China

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.129

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/EMBOJ.2010.129

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601937%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601937%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference