Contribution of p16(INK4a) to replicative senescence of human fibroblasts (Q40533302)

21 September 2017

Contribution of p16(INK4a) to replicative senescence of human fibroblasts (English)

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21 September 2017

Sharon Brookes

1

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21 September 2017

Janice Rowe

2

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21 September 2017

Ana Gutierrez Del Arroyo

3

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21 September 2017

Jane Bond

4

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21 September 2017

Gordon Peters

5

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21 September 2017

language of work or name

English

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publication date

1 August 2004

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Experimental Cell Research

21 September 2017

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21 September 2017

298

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21 September 2017

2

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21 September 2017

549-559

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The serial cultivation of human diploid cell strains

21 September 2017

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Telomere loss: mitotic clock or genetic time bomb?

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Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells

7 January 2021

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Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

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Extension of life-span by introduction of telomerase into normal human cells

7 January 2021

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Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Historical claims and current interpretations of replicative aging

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Cellular senescence: mitotic clock or culture shock?

7 January 2021

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Oxidative DNA damage and senescence of human diploid fibroblast cells.

7 January 2021

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A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

7 January 2021

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

7 January 2021

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Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes

7 January 2021

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Immortalisation and transformation revisited

7 January 2021

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A role for both RB and p53 in the regulation of human cellular senescence

7 January 2021

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Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

7 January 2021

1 reference

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

7 January 2021

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Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

7 January 2021

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Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

7 January 2021

1 reference

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Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

7 January 2021

1 reference

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

7 January 2021

1 reference

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Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

7 January 2021

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Senescence delay of human diploid fibroblast induced by anti-sense p16INK4a expression

7 January 2021

1 reference

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

7 January 2021

1 reference

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The tumor-suppressive functions of the human INK4A locus

7 January 2021

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Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts

7 January 2021

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Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

7 January 2021

1 reference

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Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

7 January 2021

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Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation

7 January 2021

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The relationship between in vitro cellular aging and in vivo human age

7 January 2021

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Chronologic and Physiologic Age Affect Replicative Life-Span of Fibroblasts from Diabetic, Prediabetic, and Normal Donors

7 January 2021

1 reference

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Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

7 January 2021

1 reference

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Role of p14(ARF) in replicative and induced senescence of human fibroblasts

7 January 2021

1 reference

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Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

7 January 2021

1 reference

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CDK inhibitors: positive and negative regulators of G1-phase progression

7 January 2021

1 reference

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Telomere position effect in human cells

7 January 2021

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Telomere states and cell fates

7 January 2021

1 reference

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The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Senescence Induced by Altered Telomere State, Not Telomere Loss

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Accumulation of short telomeres in human fibroblasts prior to replicative senescence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging

7 January 2021

1 reference

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A quantitative analysis of the aging of human glial cells in culture.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.04.035

10.1016/J.YEXCR.2004.04.035

7 January 2021

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DOI

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21 September 2017

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