Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase (Q24337721)

6

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author name string

Bing Hao

1

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Ning Zheng

2

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Brenda A Schulman

3

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Geng Wu

4

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Julie J Miller

5

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Nikola P Pavletich

Cip/Kip cyclin-dependent kinase inhibitors: brakes of the cell cycle engine during development

7

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language of work or name

English

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publication date

7 October 2005

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published in

Molecular Cell

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volume

20

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issue

1

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page(s)

9-19

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cites work

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Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

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p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

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Processing of X-ray diffraction data collected in oscillation mode

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Purification and reconstitution of cyclin-dependent kinase 2 in four states of activity

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Structural and functional diversity in the leucine-rich repeat family of proteins

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1

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Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin

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A family of mammalian F-box proteins

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Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

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A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

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Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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The murine gene p27Kip1 is haplo-insufficient for tumour suppression

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Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA

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Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

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The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

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Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins.

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A structural basis of the interactions between leucine-rich repeats and protein ligands

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

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RanGAP mediates GTP hydrolysis without an arginine finger

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

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Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

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Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

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Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes

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Role of the F-box protein Skp2 in lymphomagenesis

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Skp2 is oncogenic and overexpressed in human cancers

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Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

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Three different binding sites of Cks1 are required for p27-ubiquitin ligation

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Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

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Molecular and biochemical characterization of the Skp2-Cks1 binding interface

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Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2.

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

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Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex

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p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

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7 January 2021

Cyclin E-CDK2 is a regulator of p27Kip1.

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7 January 2021

Systematic analysis and nomenclature of mammalian F-box proteins

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CDK inhibitors: positive and negative regulators of G1-phase progression

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

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Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors

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Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

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Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome

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Noncatalytic requirement for cyclin A-cdk2 in p27 turnover

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The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex

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Mechanisms underlying ubiquitination

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SCF and Cullin/Ring H2-based ubiquitin ligases

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