Deregulated degradation of the cdk inhibitor p27 and malignant transformation. (Q34167777)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507555%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

review article

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title

Deregulated degradation of the cdk inhibitor p27 and malignant transformation (English)

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16 December 2019

2

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16 December 2019

author name string

Joanna Bloom

series ordinal

1

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16 December 2019

publication date

1 February 2003

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Seminars in Cancer Biology

16 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507555%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

volume

13

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16 December 2019

issue

1

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16 December 2019

page(s)

41-47

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Principles of CDK regulation

16 December 2019

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

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A cell cycle-regulated inhibitor of cyclin-dependent kinases

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A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells

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7 January 2021

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

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Crystal structure of cyclin-dependent kinase 2

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The dynamics of cyclin dependent kinase structure

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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Cyclin E-CDK2 is a regulator of p27Kip1.

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7 January 2021

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

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7 January 2021

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

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7 January 2021

Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome

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7 January 2021

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

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7 January 2021

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

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7 January 2021

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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7 January 2021

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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7 January 2021

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

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7 January 2021

Regulation of the G1 to S transition by the ubiquitin pathway

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7 January 2021

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

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7 January 2021

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

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7 January 2021

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

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7 January 2021

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

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7 January 2021

Translational control of p27Kip1 accumulation during the cell cycle

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7 January 2021

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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7 January 2021

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

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7 January 2021

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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7 January 2021

p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.

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7 January 2021

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

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7 January 2021

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

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7 January 2021

ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells

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7 January 2021

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

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7 January 2021

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

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7 January 2021

Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2

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7 January 2021

Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumours

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7 January 2021

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

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7 January 2021

Proteasome-dependent degradation of p27/kip1 in gliomas

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7 January 2021

Role of p27Kip1 and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer

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7 January 2021

Role of the F-box protein Skp2 in lymphomagenesis

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7 January 2021

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7 January 2021

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

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7 January 2021

S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase

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7 January 2021

p27 destruction: Cks1 pulls the trigger

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7 January 2021

Induction of hepatocyte proliferation and liver hyperplasia by the targeted expression of cyclin E and skp2

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7 January 2021

The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts

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7 January 2021

Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression

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7 January 2021

Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells

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7 January 2021

Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells

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7 January 2021

p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

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7 January 2021

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

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7 January 2021

A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

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7 January 2021

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

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7 January 2021

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

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7 January 2021