Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling (Q24338677)

negative regulation of insulin receptor signaling pathway

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Insulin receptor

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Growth factor receptor bound protein 10

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Molecular and Cellular Endocrinology

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Katsuhito Mori

1

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Barbara Giovannone

series ordinal

2

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Robert J Smith

series ordinal

3

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language of work or name

English

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publication date

31 January 2005

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published in

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volume

230

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issue

1-2

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page(s)

39-50

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CAP defines a second signalling pathway required for insulin-stimulated glucose transport

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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

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Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism

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Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

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Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity

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Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action

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The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts

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Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10.

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