Mechanism of allosteric activation of SAMHD1 by dGTP (Q24338757)

GOA release 2020-03-11

dATP catabolic process

1 reference

GOA release 2020-03-11

Angela M Gronenborn

8

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author name string

Xiaoyun Ji

1

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Ying Wu

2

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Junpeng Yan

3

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Jennifer Mehrens

4

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Haitao Yang

5

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Maria DeLucia

6

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Caili Hao

7

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Jacek Skowronski

9

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Jinwoo Ahn

10

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Yong Xiong

Nature Structural & Molecular Biology

11

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language of work or name

English

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publication date

November 2013

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published in

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volume

20

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issue

11

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page(s)

1304-9

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cites work

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Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-Substrate Complex

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Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase

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Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.

27 September 2017

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The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation

27 September 2017

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27 September 2017

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SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

27 September 2017

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SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

27 September 2017

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27 September 2017

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Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages

27 September 2017

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Homozygous mutation in SAMHD1 gene causes cerebral vasculopathy and early onset stroke

27 September 2017

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27 September 2017

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Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase

27 September 2017

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The HD domain defines a new superfamily of metal-dependent phosphohydrolases

27 September 2017

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Biochemical characterization of TT1383 from Thermus thermophilus identifies a novel dNTP triphosphohydrolase activity stimulated by dATP and dTTP.

27 September 2017

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Crossref

https://api.crossref.org/works/10.1038%2FNSMB.2692