Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells (Q24338765)

GOA release 2020-03-11

Alkaline ceramidase 1

1 reference

dihydroceramidase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Zhehao Mao

1

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Wei Sun

2

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Ruijuan Xu

3

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Sergei Novgorodov

4

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Zdzislaw M Szulc

5

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Jacek Bielawski

6

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Lina M Obeid

7

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Cungui Mao

Journal of Biological Chemistry

8

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language of work or name

English

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publication date

17 September 2010

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published in

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volume

285

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issue

38

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page(s)

29078-90

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cites work

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Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis

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Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion

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Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes

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Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

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Principles of bioactive lipid signalling: lessons from sphingolipids

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Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells

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Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls

19 March 2017

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Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides

19 March 2017

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Selective apoptosis induction by the cancer chemopreventive agent N-(4-hydroxyphenyl)retinamide is achieved by modulating mitochondrial bioenergetics in premalignant and malignant human prostate epithelial cells

19 March 2017

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Retinoids and breast cancer prevention

27 September 2017

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Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G.

27 September 2017

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De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma.

27 September 2017

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N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing

27 September 2017

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The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis

27 September 2017

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Involvement of Rac in fenretinide-induced apoptosis

27 September 2017

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Fenretinide induces autophagic cell death in caspase-defective breast cancer cells.

27 September 2017

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Fenretinide-induced apoptosis of Huh-7 hepatocellular carcinoma is retinoic acid receptor beta dependent

27 September 2017

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Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells

27 September 2017

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Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

27 September 2017

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27 September 2017

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Golgi fragmentation is associated with ceramide-induced cellular effects.

27 September 2017

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gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis

27 September 2017

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CERT mediates intermembrane transfer of various molecular species of ceramides.

27 September 2017

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Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in primary cultured cerebellar neurons.

27 September 2017

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Retinoid therapy of high-risk neuroblastoma.

27 September 2017

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Processing of gene expression data generated by quantitative real-time RT-PCR.

27 September 2017

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N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase

27 September 2017

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C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells.

27 September 2017

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Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines

27 September 2017

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N-(4-hydroxyphenyl) retinamide induces cell cycle specific growth inhibition in PC3 cells

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937939

Oral fenretinide in biochemically recurrent prostate cancer: a California cancer consortium phase II trial

27 September 2017

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Evaluation of sphinganine and sphingosine as human breast cancer chemotherapeutic and chemopreventive agents

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937939

Effect of fenretinide on ovarian carcinoma occurrence

30 May 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.105296

Randomized trial of fenretinide (4-HPR) to prevent recurrences, new localizations and carcinomas in patients operated on for oral leukoplakia: long-term results.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.105296

Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity

21 January 2018

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Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.105296

Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937939

Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells.

29 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937939

Substrate specificity of rat brain ceramidase

29 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937939

Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells

29 November 2018

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12 December 2020

Quantitation of free sphingosine in liver by high-performance liquid chromatography

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12 December 2020

Induction of apoptosis in human neuroblastoma cells by abrogation of integrin-mediated cell adhesion

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12 December 2020

Regulation of G1/S transition and induction of apoptosis in HL-60 leukemia cells by fenretinide (4HPR)

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12 December 2020

Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

1 reference

12 December 2020