Principles of bioactive lipid signalling: lessons from sphingolipids (Q28265743)

bioactive lipid receptor activity

Europe PubMed Central

title

Principles of bioactive lipid signalling: lessons from sphingolipids (English)

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main subject

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Gene Ontology release 2020-05-02

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Yusuf A Hannun

1

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Lina M Obeid

series ordinal

2

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language of work or name

English

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publication date

February 2008

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published in

Nature Reviews Molecular Cell Biology

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volume

9

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page(s)

139-50

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issue

2

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cites work

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Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

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BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome

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De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

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Tumor response to radiotherapy regulated by endothelial cell apoptosis

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Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms

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Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation

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Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway

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cca1 is required for formation of growth-arrested confluent monolayer of rat 3Y1 cells

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FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking

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Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

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Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy

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Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling

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Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators

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Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

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Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

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Essential role for sphingosine kinases in neural and vascular development

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Sphingosine-1-phosphate signaling in the cardiovascular system

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Egress: a receptor-regulated step in lymphocyte trafficking

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New immunosuppressants with potential implication in multiple sclerosis

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Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

31 March 2020

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Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2

31 March 2020

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Calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium sensor

31 March 2020

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Ceramide 1-phosphate/ceramide, a switch between life and death.

31 March 2020

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The CLN9 protein, a regulator of dihydroceramide synthase.

31 March 2020

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Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells

31 March 2020

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Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

31 March 2020

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Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development

31 March 2020

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Translational aspects of sphingolipid metabolism

31 March 2020

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Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria

31 March 2020

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Ceramides in insulin resistance and lipotoxicity

31 March 2020

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The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function

31 March 2020

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Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae

31 March 2020

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Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2329

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

235292

1023972580

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235292

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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