Inhibition of basal FGF receptor signaling by dimeric Grb2 (Q24338779)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

9

John E Ladbury

0 references

Stefan T Arold

object named as

Stefan T Arold

7

0 references

author name string

Chi-Chuan Lin

1

0 references

Fernando A Melo

2

0 references

Ragini Ghosh

3

0 references

Kin M Suen

4

0 references

Loren J Stagg

5

0 references

John Kirkpatrick

6

0 references

Zamal Ahmed

Phosphorylation and lipid raft association of fibroblast growth factor receptor-2 in oligodendrocytes

8

0 references

language of work or name

English

0 references

publication date

22 June 2012

0 references

published in

Cell

0 references

volume

149

0 references

issue

7

0 references

page(s)

1514-24

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Solution structure of Grb2 reveals extensive flexibility necessary for target recognition

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Grb2 adaptor undergoes conformational change upon dimerization

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Prediction of hydrodynamic and other solution properties of rigid proteins from atomic- and residue-level models

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Cell signaling by receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Macromolecular TLS refinement in REFMAC at moderate resolutions

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

RTK mutations and human syndromeswhen good receptors turn bad.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

HADDOCK: a protein-protein docking approach based on biochemical or biophysical information

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Fibroblast growth factor signalling: from development to cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

The FGF family: biology, pathophysiology and therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Imaging proteins in vivo using fluorescence lifetime microscopy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Fibroblast growth factors and their receptors in cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Molecular interaction studies using microscale thermophoresis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Rosetta FlexPepDock web server--high resolution modeling of peptide-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Coot: model-building tools for molecular graphics

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Crystal structure of the mammalian Grb2 adaptor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

A truncated K-sam product lacking the distal carboxyl-terminal portion provides a reduced level of autophosphorylation and greater resistance against induction of differentiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Monoclonal antibodies to fibroblast growth factor receptor 2 effectively inhibit growth of gastric tumor xenografts

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021

Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.04.033

7 January 2021