Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP (Q24339404)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Christian Siebold

14

1 reference

ORCID Public Data File 2021

Min Lu

1

Min Lu

0 references

Colin R. Goding

Colin R Goding

20

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Stefan Knapp

Stefan Knapp

11

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Benedikt M. Kessler

Benedikt M Kessler

12

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Yvonne Jones

15

E Yvonne Jones

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author name string

Hilde Breyssens

2

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Victoria Salter

3

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Shan Zhong

4

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Ying Hu

5

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Caroline Baer

6

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Indrika Ratnayaka

7

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Alex Sullivan

8

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Nicholas R Brown

9

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Jane Endicott

10

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Mark R Middleton

13

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Elena V Sviderskaya

16

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Jonathan Cebon

17

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Thomas John

18

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Otavia L Caballero

19

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Xin Lu

Amplification of CDK4 and MDM2 in malignant melanoma.

21

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language of work or name

English

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publication date

13 May 2013

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published in

Cancer Cell

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volume

23

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issue

5

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page(s)

618-33

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cites work

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Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells

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Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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ASPP proteins specifically stimulate the apoptotic function of p53

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Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

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Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53.

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iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.

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p53 rescue through HDM2 antagonism suppresses melanoma growth and potentiates MEK inhibition

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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

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iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

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MDM4 is a key therapeutic target in cutaneous melanoma

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Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma

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Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.

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The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization.

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Distinct sets of genetic alterations in melanoma

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Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo

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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

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Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification

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Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor

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Overexpression of cyclin B1 in human esophageal squamous cell carcinoma cells induces tumor cell invasive growth and metastasis

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A new role for nuclear transport factor 2 and Ran: nuclear import of CapG

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p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation

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Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis

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Resistance to MEK inhibitors: should we co-target upstream?

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Substrates of mitotic kinases

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Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences

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iASPP inhibition: increased options in targeting the p53 family for cancer therapy.

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iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe

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Contrasting effects of nutlin-3 on TRAIL- and docetaxel-induced apoptosis due to upregulation of TRAIL-R2 and Mcl-1 in human melanoma cells

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P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation

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High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays

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