The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation (Q24339411)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1904283

regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1904282

positive regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I

1 reference

Gene Ontology release 2020-05-02

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homeostatic iron regulator

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Major histocompatibility complex, class I, A

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negative regulation of CD8-positive, alpha-beta T cell activation

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author

Réjean Lapointe

4

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author name string

Alexandre Reuben

1

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Mikaël Phénix

2

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Manuela M Santos

European Journal of Immunology

3

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language of work or name

English

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publication date

June 2014

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published in

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volume

44

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page(s)

1604-14

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issue

6

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cites work

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Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

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HFE gene knockout produces mouse model of hereditary hemochromatosis

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Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man.

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Regulation of iron absorption in Hfe mutant mice

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Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

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The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

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Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function.

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Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract

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Expression of iron transport proteins divalent metal transporter-1, Ferroportin-1, HFE and transferrin receptor-1 in human monocyte-derived dendritic cells.

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Iron transport in a lymphoid cell line with the hemochromatosis C282Y mutation

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Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading

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Retrovirally transduced human dendritic cells can generate T cells recognizing multiple MHC class I and class II epitopes from the melanoma antigen glycoprotein 100.

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Stimulation of an unfolded protein response impairs MHC class I expression

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A single viral protein HCMV US2 affects antigen presentation and intracellular iron homeostasis by degradation of classical HLA class I and HFE molecules

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Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

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Regulation of growth differentiation factor 15 expression by intracellular iron.

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Cytomegaloviral control of MHC class I function in the mouse.

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The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin

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Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability

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Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses

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Loss of central and peripheral CD8+ T-cell tolerance to HFE in mouse models of human familial hemochromatosis.

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Mutations in the hemochromatosis gene (HFE) and multiple sclerosis.

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Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2.

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Yersinia pestis YopE contains a dominant CD8 T cell epitope that confers protection in a mouse model of pneumonic plague

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Endogenously expressed matrix protein M1 and nucleoprotein of influenza A are efficiently presented by class I and class II major histocompatibility complexes.

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Stimulation of Wnt/ß-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype

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Human dendritic cells require multiple activation signals for the efficient generation of tumor antigen-specific T lymphocytes

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7 January 2021

CD40 ligand and lipopolysaccharide enhance the in vitro generation of melanoma-reactive T-cells

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7 January 2021

The transferrin receptor binding site on HFE, the class I MHC-related protein mutated in hereditary hemochromatosis

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7 January 2021

HFE cross-talks with the MHC class I antigen presentation pathway

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7 January 2021

The origin and spread of the HFE-C282Y haemochromatosis mutation

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