Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase (Q24339547)

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29 February 2020

title

Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase (English)

1 reference

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SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

29 February 2020

main subject

1 reference

protein homotetramerization

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Yuhui Dong

8

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29 February 2020

author name string

Chunfeng Zhu

1

1 reference

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29 February 2020

Wenying Gao

2

1 reference

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29 February 2020

Ke Zhao

3

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29 February 2020

Xiaohong Qin

4

1 reference

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29 February 2020

Yinjie Zhang

5

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29 February 2020

Xin Peng

6

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29 February 2020

Lei Zhang

7

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29 February 2020

Wenyan Zhang

9

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29 February 2020

Peng Li

10

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29 February 2020

Wei Wei

11

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29 February 2020

Yong Gong

12

1 reference

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29 February 2020

Xiao-Fang Yu

13

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29 February 2020

language of work or name

English

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publication date

1 January 2013

1 reference

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29 February 2020

published in

Nature Communications

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29 February 2020

volume

4

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29 February 2020

page(s)

2722

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Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

29 February 2020

cites work

1 reference

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection

20 April 2017

1 reference

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

20 April 2017

1 reference

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

20 April 2017

1 reference

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells

20 April 2017

1 reference

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

20 April 2017

1 reference

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

20 April 2017

1 reference

Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection

20 April 2017

1 reference

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-Substrate Complex

20 April 2017

1 reference

Characterization of the interaction of full-length HIV-1 Vif protein with its key regulator CBFβ and CRL5 E3 ubiquitin ligase components

20 April 2017

1 reference

Phasercrystallographic software

20 April 2017

1 reference

The CCP4 suite: programs for protein crystallography

20 April 2017

1 reference

REFMAC5 for the refinement of macromolecular crystal structures

20 April 2017

1 reference

PHENIX: a comprehensive Python-based system for macromolecular structure solution

20 April 2017

1 reference

Coot: model-building tools for molecular graphics

20 April 2017

1 reference

PROCHECK: a program to check the stereochemical quality of protein structures

20 April 2017

1 reference

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

20 April 2017

1 reference

Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Homozygous mutation in SAMHD1 gene causes cerebral vasculopathy and early onset stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

A naturally immunogenic virion-associated protein specific for HIV-2 and SIV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Restricting HIV the SAMHD1 way: through nucleotide starvation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Functional analysis of the relationship between Vpx and the restriction factor SAMHD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

High frequency retrotransposition in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Determination of L1 retrotransposition kinetics in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Differential inhibition of long interspersed element 1 by APOBEC3 does not correlate with high-molecular-mass-complex formation or P-body association

21 January 2018

1 reference

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A highly active synthetic mammalian retrotransposon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

An improved plasmid DNA expression vector for direct injection into skeletal muscle

21 January 2018

1 reference

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Interaction with the p6 domain of the gag precursor mediates incorporation into virions of Vpr and Vpx proteins from primate lentiviruses

21 January 2018

1 reference

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7 January 2021

Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

7 January 2021

Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

7 January 2021

T-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restriction

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3722

7 January 2021

Identifiers

DOI

10.1038/NCOMMS3722

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3994260

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24217394%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

29 February 2020

ADS bibcode

2013NatCo...4.2722Z

0 references

1009036284

0 references

OpenCitations bibliographic resource ID

3994260

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference