The RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activation (Q24522806)

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J Jöckel

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T Quack

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C K Weber

4

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F Schmitz

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U R Rapp

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A Wittinghofer

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C Block

Molecular and Cellular Biology

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language of work or name

English

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publication date

November 1998

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published in

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volume

18

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issue

11

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page(s)

6698-710

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cites work

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

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14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

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NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions

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Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

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14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain

24 March 2017

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The complexity of Raf-1 regulation

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Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

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Two distinct Raf domains mediate interaction with Ras

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Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

24 March 2017

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Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun

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Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1

24 March 2017

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Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

24 March 2017

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A hot spot of binding energy in a hormone-receptor interface

24 March 2017

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

7 April 2017

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Activation of Raf as a result of recruitment to the plasma membrane

7 April 2017

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

7 April 2017

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Plasma membrane-targeted Raf kinase activates NF-kappaB and human immunodeficiency virus type 1 replication in T lymphocytes

10 May 2017

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KSR stimulates Raf-1 activity in a kinase-independent manner

27 September 2017

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Discrimination of amino acids mediating Ras binding from noninteracting residues affecting raf activation by double mutant analysis

27 September 2017

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Mammalian Raf-1 is activated by mutations that restore Raf signaling in Drosophila

27 September 2017

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An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

27 September 2017

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Switching to Rac and Rho.

27 September 2017

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Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase

27 September 2017

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Analysis of the ERK-stimulated ETS transcription factor ER81.

27 September 2017

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Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function

27 September 2017

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Equilibrium and kinetic measurements reveal rapidly reversible binding of Ras to Raf.

27 September 2017

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Analyzing protein-protein interactions using two-hybrid system

27 September 2017

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GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.

27 September 2017

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Function and regulation of ras.

27 September 2017

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Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

27 September 2017

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Complex formation between RAS and RAF and other protein kinases

27 September 2017

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Gene regulation by Ets proteins

27 September 2017

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The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras.

27 September 2017

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Improved method for PCR-mediated site-directed mutagenesis

27 September 2017

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Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP.

27 September 2017

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A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function

27 September 2017

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Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction

27 September 2017

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Identification of discrete segments of human Raf-1 kinase critical for high affinity binding to Ha-Ras.

27 September 2017

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Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

27 September 2017

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Raf-1 N-terminal sequences necessary for Ras-Raf interaction and signal transduction

27 September 2017

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Mutational activation of c-raf-1 and definition of the minimal transforming sequence

27 September 2017

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A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein

27 September 2017

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Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk

27 September 2017

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Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

27 September 2017

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Derivatives of activated H-ras lacking C-terminal lipid modifications retain transforming ability if targeted to the correct subcellular location

30 May 2018

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Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation

30 May 2018

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Functional mapping of the N-terminal regulatory domain in the human Raf-1 protein kinase

30 May 2018

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Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase

30 May 2018

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Chemical shift assignments and folding topology of the Ras-binding domain of human Raf-1 as determined by heteronuclear three-dimensional NMR spectroscopy.

30 May 2018

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Structural and functional epitopes in the growth hormone receptor complex

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29 November 2018

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