Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element (Q24529933)

8

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author name string

Elisabeth Balogun

1

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Martha Hoque

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Pengfei Gong

3

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Erin Killeen

4

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Colin J Green

5

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Jawed Alam

describes a project that uses

7

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language of work or name

English

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publication date

1 May 2003

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published in

Biochemical Journal

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volume

371

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page(s)

887-95

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issue

Pt 3

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enzyme assay

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western blot

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plasmid design

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transfection

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NRK-52E

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LLC-PK1

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B

24 March 2017

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An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

24 March 2017

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Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

24 March 2017

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

24 March 2017

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Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE)

24 March 2017

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

24 March 2017

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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

7 April 2017

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Regulation of heme oxygenase-1 by redox signals involving nitric oxide

7 April 2017

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Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

27 September 2017

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Activation of the mouse heme oxygenase-1 gene by 15-deoxy-Delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2.

27 September 2017

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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

27 September 2017

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Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism

27 September 2017

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The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

27 September 2017

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Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds

27 September 2017

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Cobalt induces heme oxygenase-1 expression by a hypoxia-inducible factor-independent mechanism in Chinese hamster ovary cells: regulation by Nrf2 and MafG transcription factors

27 September 2017

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Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

27 September 2017

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Regulation of genes encoding NAD(P)H:quinone oxidoreductases

27 September 2017

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Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1.

27 September 2017

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Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor

27 September 2017

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Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

27 September 2017

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The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis

27 September 2017

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Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.

27 September 2017

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Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis.

27 September 2017

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Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury

27 September 2017

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Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells

27 September 2017

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NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium

27 September 2017

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Identification of a second region upstream of the mouse heme oxygenase-1 gene that functions as a basal level and inducer-dependent transcription enhancer

27 September 2017

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Nrf2 and c-Jun regulation of antioxidant response element (ARE)-mediated expression and induction of gamma-glutamylcysteine synthetase heavy subunit gene

27 September 2017

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Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers

30 May 2018

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Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities.

29 November 2018

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Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells

29 November 2018

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Nrf2-deficient female mice develop lupus-like autoimmune nephritis

29 November 2018

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Inhibitory effects of curcumin on tumorigenesis in mice.

29 November 2018

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Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice

29 November 2018

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12 December 2020

Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue

1 reference

12 December 2020

Heme Oxygenase-1–Derived Carbon Monoxide Contributes to the Suppression of Acute Hypertensive Responses In Vivo

1 reference

12 December 2020

Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation

1 reference

12 December 2020

Thiol Compounds Interact with Nitric Oxide in Regulating Heme Oxygenase-1 Induction in Endothelial Cells

1 reference

12 December 2020

Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction

1 reference

12 December 2020

Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress

1 reference

12 December 2020