Probing serpin reactive-loop conformations by proteolytic cleavage (Q24534215)

24 March 2024

M R Wardell

series ordinal

2

author given names

M R

author last names

Wardell

1 reference

24 March 2024

D A Lomas

series ordinal

3

author given names

D A

author last names

Lomas

1 reference

24 March 2024

R W Carrell

series ordinal

4

author given names

R W

author last names

Carrell

1 reference

Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

24 March 2024

language of work or name

English

0 references

publication date

1 March 1996

0 references

published in

Biochemical Journal

0 references

volume

314 ( Pt 2)

0 references

page(s)

647-53

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Crystal structure of cleaved bovine antithrombin III at 3.2 A resolution

24 March 2017

1 reference

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The serpin superfamily of proteinase inhibitors: structure, function, and regulation

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Biological implications of a 3 A structure of dimeric antithrombin

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

On the size of the active site in proteases. I. Papain

24 March 2017

1 reference

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

24 March 2017

1 reference

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Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Protein inhibitors of proteinases

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

The role of conformational change in serpin structure and function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Effects of mutations in the hinge region of serpins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Antithrombin and its inherited deficiencies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

27 September 2017

1 reference

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Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Antithrombin: the principal inhibitor of thrombin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

What do dysfunctional serpins tell us about molecular mobility and disease?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Crystal structure of ovalbumin as a model for the reactive centre of serpins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Antithrombin III: structural and functional aspects

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Structure-function studies of the SERPIN plasminogen activator inhibitor type 1. Analysis of chimeric strained loop mutants

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Serpins: implications of a mobile reactive centre

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

The Size and Shape of Human and Bovine Antithrombin III

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

An examination of the inhibitory mechanism of serpins by analysing the interaction of trypsin and chymotrypsin with alpha 2-antiplasmin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Inactivation of human antithrombin by neutrophil elastase. Kinetics of the heparin-dependent reaction.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Structural transition of alpha 1-antitrypsin by a peptide sequentially similar to beta-strand s4A.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

A 1H NMR probe for mobility in the reactive center loops of serpins: spin-echo studies of native and modified forms of ovalbumin and alpha 1-proteinase inhibitor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Structural basis of latency in plasminogen activator inhibitor-1

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217096

Preparation and characterization of latent alpha 1-antitrypsin

29 November 2018

1 reference

12 December 2020

Inhibition of acrosin by serpins. A suicide substrate mechanism

1 reference

12 December 2020

Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop

1 reference

12 December 2020

A mechanism for heparin-induced potentiation of antithrombin III

1 reference

12 December 2020

Release of a Two-Chain Form of Antithrombin from the Antithrombin-Thrombin Complex

1 reference

12 December 2020

A simple two-step procedure for the isolation of antithrombin III from biological fluids

1 reference

12 December 2020

Heparin promotes the inactivation of antithrombin by neutrophil elastase

1 reference

12 December 2020

Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites

1 reference

12 December 2020

Substrate properties of C1 inhibitor Ma (alanine 434----glutamic acid). Genetic and structural evidence suggesting that the P12-region contains critical determinants of serine protease inhibitor/substrate status

1 reference

12 December 2020

Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate

1 reference

12 December 2020

Inhibitory activity and conformational transition of alpha1-proteinase inhibitor variants

1 reference

12 December 2020

Type-1 inhibitor of plasminogen activators. Distinction between latent, activated and reactive centre-cleaved forms with thermal stability and monoclonal antibodies

1 reference

12 December 2020

Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of

1 reference

12 December 2020

Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis

1 reference

12 December 2020

Evidence for the extent of insertion of the active site loop of intact alpha 1 proteinase inhibitor in beta-sheet A

1 reference

12 December 2020

Kinetic characterization of the substrate reaction between a complex of antithrombin with a synthetic reactive-bond loop tetradecapeptide and four target proteinases of the inhibitor

1 reference

12 December 2020

Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

1 reference

12 December 2020

Immunologic evidence for insertion of the reactive-bond loop of antithrombin into the A beta-sheet of the inhibitor during trapping of target proteinases

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ3140647

1 reference

Consolidated OpenCitations Corpus – April 2017

release_weyiiwmorrbujjq2og375uzury

Fatcat ID

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

PMC publication ID

1217096

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017