Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis. (Q24534867)

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English	Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.	scientific article

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10 November 2019

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis (English)

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10 November 2019

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Aislinn Williams

4

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10 November 2019

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Yaohui Chai

1

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10 November 2019

Jianqiang Shao

2

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10 November 2019

Victor M Miller

3

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10 November 2019

Henry L Paulson

5

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10 November 2019

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25 June 2002

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10 November 2019

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6

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Proceedings of the National Academy of Sciences of the United States of America

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10 November 2019

99

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10 November 2019

14

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10 November 2019

9310-9315

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10 November 2019

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

1 reference

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24 March 2017

Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

24 March 2017

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

1 reference

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24 March 2017

Ataxin-3 is transported into the nucleus and associates with the nuclear matrix

1 reference

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24 March 2017

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

1 reference

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24 March 2017

Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain

1 reference

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24 March 2017

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

1 reference

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24 March 2017

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

7 April 2017

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

7 April 2017

High mobility of proteins in the mammalian cell nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

7 April 2017

Histone deacetylase inhibitors reduce polyglutamine toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

27 September 2017

Protein mobility within the nucleus--what are the right moves?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

27 September 2017

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

27 September 2017

CREB-binding protein sequestration by expanded polyglutamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

27 September 2017

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

27 September 2017

Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

27 September 2017

Ataxin-3 with an altered conformation that exposes the polyglutamine domain is associated with the nuclear matrix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

27 September 2017

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

27 September 2017

High level expression of expanded full-length ataxin-3 in vitro causes cell death and formation of intranuclear inclusions in neuronal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

27 September 2017

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

27 September 2017

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

27 September 2017

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

1 reference

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27 September 2017

Genetic suppression of polyglutamine toxicity in Drosophila

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123137

30 May 2018

Expansion explosion: new clues to the pathogenesis of repeat expansion neurodegenerative diseases

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21 January 2018

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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21 January 2018

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

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21 January 2018

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

1 reference

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21 January 2018

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.152101299

21 January 2018

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.152101299

21 January 2018

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

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21 January 2018

Nuclear targeting of mutant Huntingtin increases toxicity

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.152101299

21 January 2018

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.152101299

21 January 2018

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

1 reference

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21 January 2018

The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.152101299

21 January 2018

FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent

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21 January 2018

Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies

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21 January 2018

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

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21 January 2018

The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease

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21 January 2018

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

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12 December 2020

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10.1073/PNAS.152101299

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10 November 2019

2002PNAS...99.9310C

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10 November 2019

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10 November 2019

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