CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis (Q24540387)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12529437%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

title

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12529437%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

0 references

1 reference

7

1 reference

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16 December 2019

Ludger Hengst

8

1 reference

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16 December 2019

author name string

Michael K Connor

1

1 reference

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16 December 2019

Rouslan Kotchetkov

2

1 reference

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16 December 2019

Sandrine Cariou

3

1 reference

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16 December 2019

Ansgar Resch

4

1 reference

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16 December 2019

Rafaella Lupetti

5

1 reference

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16 December 2019

Richard G Beniston

6

1 reference

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16 December 2019

Joyce M Slingerland

9

1 reference

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16 December 2019

language of work or name

English

0 references

publication date

1 January 2003

1 reference

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Molecular Biology of the Cell

16 December 2019

published in

1 reference

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16 December 2019

volume

14

1 reference

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16 December 2019

page(s)

201-213

1 reference

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16 December 2019

issue

1

1 reference

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A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

16 December 2019

cites work

1 reference

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Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

24 March 2017

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Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex

24 March 2017

1 reference

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Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export

24 March 2017

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Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

24 March 2017

1 reference

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

24 March 2017

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Nuclear localization of cyclin B1 controls mitotic entry after DNA damage

24 March 2017

1 reference

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New functional activities for the p21 family of CDK inhibitors

24 March 2017

1 reference

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The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B

24 March 2017

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Transport between the cell nucleus and the cytoplasm

24 March 2017

1 reference

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Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha

24 March 2017

1 reference

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CRM1 is an export receptor for leucine-rich nuclear export signals

24 March 2017

1 reference

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The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.

24 March 2017

1 reference

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Exportin 1 (Crm1p) is an essential nuclear export factor

24 March 2017

1 reference

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Nucleocytoplasmic transport: the soluble phase

24 March 2017

1 reference

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Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

The ran decathlon: multiple roles of Ran

24 March 2017

1 reference

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

24 March 2017

1 reference

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

24 March 2017

1 reference

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Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1

24 March 2017

1 reference

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Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

24 March 2017

1 reference

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CRM1 is responsible for intracellular transport mediated by the nuclear export signal

24 March 2017

1 reference

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Nucleocytoplasmic transport: signals, mechanisms and regulation

7 April 2017

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The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

7 April 2017

1 reference

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Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor

7 April 2017

1 reference

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

7 April 2017

1 reference

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Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1.

7 April 2017

1 reference

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Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

The role of Ran in nuclear function.

27 September 2017

1 reference

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Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Regulation of the cdk inhibitor p27 and its deregulation in cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Nuclear transport: randy couples

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay

27 September 2017

1 reference

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A cell cycle-regulated inhibitor of cyclin-dependent kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Posttranscriptional effector domains in the Rev proteins of feline immunodeficiency virus and equine infectious anemia virus.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Translational control of p27Kip1 accumulation during the cell cycle

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Nuclear protein import in a permeabilized cell assay.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitro

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Cyclin E-CDK2 is a regulator of p27Kip1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Two-way trafficking with Ran.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140238

Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12529437

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nuclear protein import using digitonin-permeabilized cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12529437

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1091/MBC.E02-06-0319

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12529437%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12529437%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

2 references