Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis (Q24542413)

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18 January 2020

title

Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis (English)

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18 January 2020

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Alessandra S Eustáquio

2

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18 January 2020

Lutz Heide

4

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18 January 2020

Anthony Maxwell

5

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18 January 2020

author name string

Ruth H Flatman

1

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18 January 2020

Shu-Ming Li

3

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18 January 2020

language of work or name

English

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publication date

1 April 2006

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Antimicrobial Agents and Chemotherapy

18 January 2020

number of pages

7

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based on heuristic

inferred from page(s)

published in

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18 January 2020

volume

50

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18 January 2020

issue

4

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18 January 2020

page(s)

1136-1142

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The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study

18 January 2020

cites work

1 reference

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The ATP-binding site of type II topoisomerases as a target for antibacterial drugs

24 March 2017

1 reference

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New aminocoumarin antibiotics from genetically engineered Streptomyces strains.

24 March 2017

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Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis.

27 September 2017

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Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin

27 September 2017

1 reference

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Fluoroquinolones: action and resistance

27 September 2017

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Quinolone-binding pocket of DNA gyrase: role of GyrB.

27 September 2017

1 reference

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Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115.

27 September 2017

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DNA gyrase as a drug target

27 September 2017

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The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography

27 September 2017

1 reference

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Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters

27 September 2017

1 reference

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DNA gyrase and topoisomerase IV: biochemical activities, physiological roles during chromosome replication, and drug sensitivities.

30 May 2018

1 reference

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The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

30 May 2018

1 reference

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Expression and analysis of two gyrB genes from the novobiocin producer, Streptomyces sphaeroides

30 May 2018

1 reference

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Metabolic engineering of aminocoumarins: inactivation of the methyltransferase gene cloP and generation of new clorobiocin derivatives in a heterologous host

30 May 2018

1 reference

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Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains.

29 November 2018

1 reference

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Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489.

29 November 2018

1 reference

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CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin

29 November 2018

1 reference

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Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs.

29 November 2018

1 reference

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Synthesis and in vitro evaluation of novel highly potent coumarin inhibitors of gyrase B.

29 November 2018

1 reference

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Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions.

29 November 2018

1 reference

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Tryptic fragments of the Escherichia coli DNA gyrase A protein.

29 November 2018

1 reference

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Overexpression and purification of bacterial DNA gyrase.

29 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1128%2FAAC.50.4.1136-1142.2006

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7 January 2021

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Identifiers

DOI

10.1128/AAC.50.4.1136-1142.2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16569821%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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18 January 2020

1 reference