Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease (Q24548705)

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J Travis

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E J Helmerhorst

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R F Troxler

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F G Oppenheim

Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans

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language of work or name

English

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publication date

March 2001

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published in

Infection and Immunity

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volume

69

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issue

3

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page(s)

1402-8

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cites work

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Identification of Full-Sized Forms of Salivary (Type) Cystatins (Cystatin SN, Cystatin SA, Cystatin S, and Two Phosphorylated Forms of Cystatin S) in Human Whole Saliva and Determination of Phosphorylation Sites of Cystatin S

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Zn(2+) ions selectively induce antimicrobial salivary peptide histatin-5 to fuse negatively charged vesicles. Identification and characterization of a zinc-binding motif present in the functional domain

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Characterization and amino acid sequence of a new acidic cysteine proteinase inhibitor (cystatin SA) structurally closely related to cystatin S, from human whole saliva

27 September 2017

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A protease of Bacteroides gingivalis degrades cell surface and matrix glycoproteins of cultured gingival fibroblasts and induces secretion of collagenase and plasminogen activator.

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Anticandidal activity of major human salivary histatins

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Sequence analysis and characterization of the Porphyromonas gingivalis prtC gene, which expresses a novel collagenase activity

27 September 2017

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27 September 2017

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An assay for detecting nanogram levels of proteolytic enzymes.

30 May 2018

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Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis.

30 May 2018

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30 May 2018

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Is salivary histatin 5 a metallopeptide?

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Salivary histatin as an inhibitor of a protease produced by the oral bacterium Bacteroides gingivalis

28 November 2018

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Salivary enzymes. Origin and relationship to periodontal disease

28 November 2018

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12 December 2020

Degradation of human immunoglobulins G and M and complement factors C3 and C5 by black-pigmented Bacteroides

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12 December 2020

Characterization of collagenolytic activity from strains of Bacteroides gingivalis

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12 December 2020

Elevation of salivary antimicrobial proteins following HIV-1 infection

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12 December 2020

Characteristics of human salivary collagenase and its relationship to periodontal diseases

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Histatin 5 is a substrate and not an inhibitor of the Arg- and Lys-specific proteinases of Porphyromonas gingivalis

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12 December 2020

The relationship between salivary histatin levels and oral yeast carriage

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Cathepsin L is capable of truncating cystatin C of 11 N-terminal amino acids

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The role of gingival crevicular fluid and salivary interstitial collagenases in human periodontal diseases

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Multiple forms of gelatinases/type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients

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Inhibitory activities of partially degraded salivary cystatins

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Matrix metalloproteinases (MMP-2 and MMP-9) of the oral cavity: cellular origin and relationship to periodontal status

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Gingival crevicular fluid and salivary matrix metalloproteinases of heavy smokers as indicators of periodontal health

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Physiological regulation of the secretion of histatins and statherins in human parotid saliva

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