The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit (Q24554509)

1

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M I Torres-Arzayus

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S T Rottinghaus

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G E Taccioli

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P A Jeggo

Molecular and Cellular Biology

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language of work or name

English

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publication date

May 1999

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published in

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volume

19

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issue

5

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page(s)

3267-77

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cites work

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Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

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cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen

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Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

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The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

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Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20

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A central region of Ku80 mediates interaction with Ku70 in vivo

27 September 2017

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DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

27 September 2017

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Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions

27 September 2017

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Defining the minimal domain of Ku80 for interaction with Ku70.

27 September 2017

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Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

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27 September 2017

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Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

27 September 2017

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Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86.

27 September 2017

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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

27 September 2017

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Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

27 September 2017

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Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair

27 September 2017

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DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

27 September 2017

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Menage à trois: double strand break repair, V(D)J recombination and DNA-PK.

27 September 2017

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A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation

27 September 2017

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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

27 September 2017

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DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

27 September 2017

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Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells

27 September 2017

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X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

27 September 2017

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Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen

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Azacytidine-induced reactivation of a DNA repair gene in Chinese hamster ovary cells

27 September 2017

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scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair

27 September 2017

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A link between double-strand break-related repair and V(D)J recombination: the scid mutation

27 September 2017

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Activities involved in V(D)J recombination

27 September 2017

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Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

27 September 2017

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The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene

27 September 2017

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Characterization of a Ku86 variant protein that results in altered DNA binding and diminished DNA-dependent protein kinase activity

27 September 2017

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Recent advances in understanding V(D)J recombination.

27 September 2017

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DNA-PK: at the cross-roads of biochemistry and genetics

27 September 2017

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V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair

30 May 2018

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Impairment of V(D)J recombination in double-strand break repair mutants

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84121

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

30 May 2018

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In vivo competition between a metallothionein regulatory element and the SV40 enhancer

30 May 2018

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Decreased stable transfection frequencies of six X-ray-sensitive CHO strains, all members of the xrs complementation group

30 May 2018

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Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant

30 May 2018

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12 December 2020

Regulation of DNA-dependent protein kinase activity in leukemic cells

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12 December 2020

Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding

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12 December 2020

The scid mutation in mice causes a general defect in DNA repair

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12 December 2020

Site-specific proteolytic cleavage of Ku protein bound to DNA

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12 December 2020