Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice (Q24563208)

2

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D J Rader

3

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R Tangirala

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S Fazio

5

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M F Linton

6

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C D Funk

Journal of Clinical Investigation

7

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language of work or name

English

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publication date

June 1999

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published in

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volume

103

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page(s)

1597-604

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issue

11

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cites work

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27 September 2017

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27 September 2017

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27 September 2017

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30 May 2018

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Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408369

Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions

30 May 2018

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ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

30 May 2018

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The rabbit 15-lipoxygenase preferentially oxygenates LDL cholesterol esters, and this reaction does not require vitamin E.

30 May 2018

1 reference

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Nomenclature of isoprostanes: a proposal.

28 November 2018

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Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408369

Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408369

Involvement of 15-lipoxygenase in early stages of atherogenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408369

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408369

Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases

28 November 2018

1 reference

12 December 2020

Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis

1 reference

12 December 2020

Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of alpha-tocopherol and ascorbate

1 reference

12 December 2020

Cytokine modulation of LDL oxidation by activated human monocytes

1 reference

12 December 2020

A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit

1 reference

12 December 2020

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

1 reference

12 December 2020

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree

1 reference

12 December 2020

Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

1 reference

12 December 2020

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation

1 reference

12 December 2020

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI5897

1 reference

2137406

2137406

1 reference

1 reference

1 reference