Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease (Q24597322)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23214987%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23214987%20AND%20SRC:MED&resulttype=core&format=json

neglected tropical disease

19 February 2020

main subject

organic chemistry

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1 reference

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5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23214987%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

author name string

Mark C Dobish

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23214987%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Fernando Villalta

2

1 reference

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19 February 2020

Michael R Waterman

3

1 reference

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19 February 2020

Galina I Lepesheva

4

1 reference

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19 February 2020

language of work or name

English

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publication date

7 December 2012

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19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23214987%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

volume

14

1 reference

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19 February 2020

page(s)

6322-6325

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19 February 2020

issue

24

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CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds

19 February 2020

cites work

1 reference

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VNI cures acute and chronic experimental Chagas disease

24 March 2017

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Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

24 March 2017

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A Concise Synthesis of (+)-Artemisinin

24 March 2017

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In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi

24 March 2017

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Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

24 March 2017

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Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy

24 March 2017

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Preparation of H,(4) PyrrolidineQuin-BAM (PBAM).

24 March 2017

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Stereocontrolled organocatalytic synthesis of prostaglandin PGF2α in seven steps

27 September 2017

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Current and developing therapeutic agents in the treatment of Chagas disease

27 September 2017

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Advances in Chagas disease drug development: 2009-2010

27 September 2017

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Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.

27 September 2017

1 reference

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A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection

27 September 2017

1 reference

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Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase

27 September 2017

1 reference

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Bifunctional asymmetric catalysis: amplification of Brønsted basicity can orthogonally increase the reactivity of a chiral Brønsted acid.

27 September 2017

1 reference

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Catalytic asymmetric direct Mannich reaction: a powerful tool for the synthesis of alpha,beta-diamino acids.

27 September 2017

1 reference

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CYP51: A major drug target in the cytochrome P450 superfamily

27 September 2017

1 reference

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Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth

27 September 2017

1 reference

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CYP51--the omnipotent P450.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528807

Chiral proton catalysis: a catalytic enantioselective direct aza-Henry reaction.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528807

Specific chemotherapy of Chagas disease: controversies and advances

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528807

Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528807

Chiral Brønsted base-promoted nitroalkane alkylation: enantioselective synthesis of sec-alkyl-3-substituted indoles

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528807

A Novel Bis-Thiourea Organocatalyst for the Asymmetric Aza-Henry Reaction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528807

Recent Developments in Sterol 14-demethylase Inhibitors for Chagas Disease.

30 May 2018

1 reference

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Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor

30 May 2018

1 reference

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Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor

30 May 2018

1 reference

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Umpolung reactivity in amide and peptide synthesis

30 May 2018

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Chagas disease: a new worldwide challenge.

30 May 2018

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28 November 2018

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Chagas disease: pushing through the pipeline

28 November 2018

1 reference

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A diastereo- and enantioselective synthesis of alpha-substituted syn-alpha,beta-diamino acids

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528807

Organocatalytic asymmetric Mannich reactions with N-Boc and N-Cbz protected alpha-amido sulfones (Boc: tert-butoxycarbonyl, Cbz: benzyloxycarbonyl)

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528807

Chiral proton catalysis: enantioselective Brønsted acid catalyzed additions of nitroacetic acid derivatives as glycine equivalents

28 November 2018

1 reference

12 December 2020

A formal enantioselective acetate Mannich reaction: the nitro functional group as a traceless agent for activation and enantiocontrol in the synthesis of beta-amino acids

1 reference

12 December 2020

Highly anti-selective asymmetric nitro-mannich reactions catalyzed by bifunctional amine-thiourea-bearing multiple hydrogen-bonding donors

1 reference

12 December 2020

Brønsted-Acid-Catalyzed Activation of Nitroalkanes: A Direct Enantioselective Aza-Henry Reaction

1 reference

12 December 2020

Alpha-amido sulfones as stable precursors of reactive N-acylimino derivatives

1 reference

12 December 2020

Identifiers

DOI

10.1021/OL303092V

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23214987%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23214987%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference