Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice (Q24597354)

14

0 references

Rafael de Cabo

object named as

Rafael de Cabo

6

0 references

Richard A. Miller

1

object named as

Richard A Miller

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author name string

David E Harrison

2

0 references

C M Astle

3

0 references

Angela Rodriguez Boyd

5

0 references

Elizabeth Fernandez

7

0 references

Kevin Flurkey

8

0 references

Martin A Javors

9

0 references

James F Nelson

10

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Carlos J Orihuela

11

0 references

Scott Pletcher

12

0 references

Zelton Dave Sharp

13

0 references

Joseph W Starnes

15

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J Erby Wilkinson

16

0 references

Nancy L Nadon

17

0 references

Randy Strong

The Journals of Gerontology

18

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language of work or name

English

0 references

publication date

February 2011

0 references

published in

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volume

66

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issue

2

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page(s)

191-201

0 references

cites work

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

24 March 2017

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The TOR pathway comes of age

24 March 2017

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

24 March 2017

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Extension of chronological life span in yeast by decreased TOR pathway signaling

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

24 March 2017

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

24 March 2017

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Resveratrol improves health and survival of mice on a high-calorie diet

24 March 2017

1 reference

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

24 March 2017

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24 March 2017

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

7 April 2017

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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27 September 2017

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27 September 2017

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Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age

27 September 2017

1 reference

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Targeting the mTOR pathway using deforolimus in cancer therapy

27 September 2017

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27 September 2017

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Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

27 September 2017

1 reference

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27 September 2017

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27 September 2017

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Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

27 September 2017

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Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.

27 September 2017

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The expanding TOR signaling network

27 September 2017

1 reference

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27 September 2017

1 reference

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An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster

27 September 2017

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The molecular target of rapamycin (mTOR) as a therapeutic target against cancer

27 September 2017

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27 September 2017

1 reference

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Prostate cancer and PSA among statin users in the Finnish prostate cancer screening trial.

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021372

Ageing: A midlife longevity drug?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021372

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021372

Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021372

Statistical methods for testing effects on “maximum lifespan”

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021372

Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021372

Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021372

HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021372

Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021372

Role of cardiac ATP-sensitive K+ channels induced by HMG CoA reductase inhibitor in ischemic rabbit hearts

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021372

Program for testing biological interventions to promote healthy aging

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20974732

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Deforolimus (AP23573) a novel mTOR inhibitor in clinical development

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20974732

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/GERONA/GLQ178

1 reference

554413

554413

1 reference

1 reference

1 reference