Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta (Q24598068)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11090130%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

title

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta (English)

1 reference

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Cytochrome P450, family 7, subfamily a, polypeptide 1

2 November 2019

main subject

1 reference

Nuclear receptor subfamily 1, group H, member 3

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Sterol regulatory element binding transcription factor 1

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Sterol regulatory element binding factor 2

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Stearoyl-Coenzyme A desaturase 1

1 reference

author

David Mangelsdorf

10

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2 November 2019

author name string

J J Repa

1

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2 November 2019

G Liang

2

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2 November 2019

J Ou

3

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2 November 2019

Y Bashmakov

4

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2 November 2019

J M Lobaccaro

5

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2 November 2019

I Shimomura

6

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2 November 2019

B Shan

7

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2 November 2019

M S Brown

8

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2 November 2019

J L Goldstein

9

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2 November 2019

language of work or name

English

0 references

publication date

1 November 2000

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2 November 2019

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2 November 2019

volume

14

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2 November 2019

page(s)

2819-2830

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2 November 2019

issue

22

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Role of LXRs in control of lipogenesis

2 November 2019

cites work

1 reference

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24 March 2017

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Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

24 March 2017

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24 March 2017

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Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

24 March 2017

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24 March 2017

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24 March 2017

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The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1

24 March 2017

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Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

24 March 2017

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Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

24 March 2017

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

24 March 2017

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An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

24 March 2017

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SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

24 March 2017

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Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

24 March 2017

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Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase

24 March 2017

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Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

24 March 2017

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Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2

24 March 2017

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Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins

24 March 2017

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Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

24 March 2017

1 reference

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The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

24 March 2017

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Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action

27 September 2017

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Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene

27 September 2017

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Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor

27 September 2017

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Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

27 September 2017

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Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element

27 September 2017

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Oxysterols: modulators of cholesterol metabolism and other processes

27 September 2017

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Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

27 September 2017

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Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

27 September 2017

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Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

27 September 2017

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27 September 2017

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Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

27 September 2017

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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

27 September 2017

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Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

27 September 2017

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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

27 September 2017

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Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver

27 September 2017

1 reference

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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

27 September 2017

1 reference

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Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.

27 September 2017

1 reference

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Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

27 September 2017

1 reference

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ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation

27 September 2017

1 reference

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Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells

27 September 2017

1 reference

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ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism

27 September 2017

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A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

30 May 2018

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12 December 2020

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

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12 December 2020

Influence of dietary cholesterol on desaturase enzymes of rat liver microsomes

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12 December 2020

Initial clinical trial of a selective retinoid X receptor ligand, LGD1069

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12 December 2020

Dietary cholesterol and the activity of stearoyl CoA desaturase in rats: evidence for an indirect regulatory effect

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12 December 2020

Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs

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12 December 2020

Regulation of hepatic 7 alpha-hydroxylase expression and response to dietary cholesterol in the rat and hamster

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12 December 2020

Identifiers

DOI

10.1101/GAD.844900

2 references

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2 November 2019

1 reference

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2 November 2019

2 references