Markers of resistance to anti-EGFR therapy in colorectal cancer (Q24598640)

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

volume

4

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issue

3

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page(s)

308-18

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cites work

1 reference

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24 March 2017

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24 March 2017

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Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab

24 March 2017

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Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

24 March 2017

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24 March 2017

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24 March 2017

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24 March 2017

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24 March 2017

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24 March 2017

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Untangling the ErbB signalling network

24 March 2017

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

24 March 2017

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High frequency of mutations of the PIK3CA gene in human cancers

24 March 2017

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Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer

24 March 2017

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BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer

24 March 2017

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Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status

24 March 2017

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Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study

7 April 2017

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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

7 April 2017

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Concordant KRAS mutations in primary and metastatic colorectal cancer tissue specimens: a meta-analysis and systematic review

7 April 2017

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MAP kinase genes and colon and rectal cancer

27 September 2017

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Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas

27 September 2017

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Randomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer

27 September 2017

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27 September 2017

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KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer.

27 September 2017

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Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance

27 September 2017

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Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

27 September 2017

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27 September 2017

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Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

27 September 2017

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Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy

27 September 2017

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Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines

27 September 2017

1 reference

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Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.

27 September 2017

1 reference

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Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.

27 September 2017

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27 September 2017

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PTEN gene mutations in colorectal cancers displaying microsatellite instability

27 September 2017

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27 September 2017

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27 September 2017

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Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer

27 September 2017

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Oncogenic RAF: a brief history of time

30 May 2018

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30 May 2018

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Functional analysis of PIK3CA gene mutations in human colorectal cancer

30 May 2018

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30 May 2018

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30 May 2018

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28 November 2018

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28 November 2018

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28 November 2018

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KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial

28 November 2018

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28 November 2018

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EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer

28 November 2018

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Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers.

28 November 2018

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KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab

28 November 2018

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Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

28 November 2018

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BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair

28 November 2018

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Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer

28 November 2018

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12 December 2020

Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab

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12 December 2020

EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients

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12 December 2020

Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab

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12 December 2020

Poor Survival Associated with theBRAFV600E Mutation in Microsatellite-Stable Colon Cancers

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12 December 2020

Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII study

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12 December 2020

Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis

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12 December 2020

Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab

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12 December 2020

Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models

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12 December 2020

FDA approves aflibercept (Zaltrap) for metastatic colorectal cancer

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12 December 2020

Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice

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12 December 2020