Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf (Q24598824)

Isoprenylcysteine carboxyl methyltransferase

GOA release 2020-03-11

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GOA release 2020-03-11

4

Anne P Beigneux

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author name string

Martin O Bergo

1

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Bryant J Gavino

2

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Christine Hong

3

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Martin McMahon

5

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Patrick J Casey

6

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Stephen G Young

Journal of Clinical Investigation

7

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language of work or name

English

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publication date

February 2004

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published in

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volume

113

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page(s)

539-50

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issue

4

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cites work

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Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells

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Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice

24 March 2017

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Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

24 March 2017

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7 April 2017

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27 September 2017

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Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation

27 September 2017

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Ras and Rho regulation of the cell cycle and oncogenesis

27 September 2017

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27 September 2017

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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

27 September 2017

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The farnesyl transferase inhibitor SCH 66336 induces a G(2) --> M or G(1) pause in sensitive human tumor cell lines

27 September 2017

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27 September 2017

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Post-translational processing of RhoA. Carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of Rhoa

27 September 2017

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The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

27 September 2017

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

27 September 2017

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Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

27 September 2017

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Inhibitors of Ras farnesyltransferases

27 September 2017

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Overexpression of transforming growth factor-alpha causes liver enlargement and increased hepatocyte proliferation in transgenic mice

27 September 2017

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Tumorigenicity of fibroblast lines expressing the adenovirus E1a, cellular p53, or normal c-myc genes

27 September 2017

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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

27 September 2017

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Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins

27 September 2017

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Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

27 September 2017

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A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells.

27 September 2017

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Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

30 May 2018

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Farnesyltransferase inhibitors versus Ras inhibitors.

30 May 2018

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Ras signalling on the endoplasmic reticulum and the Golgi

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=338259

Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=338259

Rho family proteins and Ras transformation: the RHOad less traveled gets congested.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=338259

Signal transduction. Why Ras needs Rho.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=338259

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28 November 2018

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