O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability (Q24602222)

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K Su

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M D Roos

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Q Chang

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A J Paterson

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J E Kudlow

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

5 June 2001

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published in

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volume

98

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page(s)

6611-6

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issue

12

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cites work

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

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The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny

7 April 2017

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O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions

7 April 2017

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Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

7 April 2017

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O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation

7 April 2017

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Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity

7 April 2017

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Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

7 April 2017

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Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells

7 April 2017

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Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators

7 April 2017

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Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death

7 April 2017

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O-GlcNAc and the control of gene expression

27 September 2017

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Streptozotocin, an analog of N-acetylglucosamine, blocks the removal of O-GlcNAc from intracellular proteins.

27 September 2017

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A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.

27 September 2017

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Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

27 September 2017

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High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells

27 September 2017

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Dynamic O-linked glycosylation of nuclear and cytoskeletal proteins

27 September 2017

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Role of the glucosamine pathway in fat-induced insulin resistance

27 September 2017

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Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility

27 September 2017

1 reference

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A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34401

Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.

27 September 2017

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The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34401

Role of glucosamine synthesis in the stimulation of TGF-alpha gene transcription by glucose and EGF.

27 September 2017

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The subcellular distribution of terminal N-acetylglucosamine moieties. Localization of a novel protein-saccharide linkage, O-linked GlcNAc.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34401

Distinct regions of Sp1 modulate DNA binding and transcriptional activation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34401

Glycosylation of chromosomal proteins: localization of O-linked N-acetylglucosamine in Drosophila chromatin.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34401

Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34401

Transcription from a TATA-less promoter requires a multisubunit TFIID complex

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34401

Critical structural elements of the VP16 transcriptional activation domain

30 May 2018

1 reference

12 December 2020

RNA polymerase II is a glycoprotein. Modification of the COOH-terminal domain by O-GlcNAc

1 reference

12 December 2020

Glucose metabolism to glucosamine is necessary for glucose stimulation of transforming growth factor-alpha gene transcription.

1 reference

12 December 2020

The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake

1 reference

12 December 2020

Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo

1 reference

12 December 2020

Elevated O-linked N-acetylglucosamine metabolism in pancreatic beta-cells

1 reference

12 December 2020

An N-terminal region of Sp1 targets its proteasome-dependent degradation in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.111099998

1 reference

1508848

ADS bibcode

2001PNAS...98.6611Y

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1508848

1 reference

1 reference

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