Obesity and insulin resistance (Q24607078)

Journal of Clinical Investigation

Europe PubMed Central

title

Obesity and insulin resistance (English)

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J S Flier

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Barbara Kahn

series ordinal

1

object named as

B B Kahn

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language of work or name

English

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publication date

August 2000

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published in

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volume

106

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page(s)

473-81

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issue

4

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cites work

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

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Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

7 April 2017

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Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein

7 April 2017

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Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes

7 April 2017

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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

7 April 2017

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Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt

7 April 2017

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Does central obesity reflect "Cushing's disease of the omentum"?

7 April 2017

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Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

7 April 2017

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Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport

7 April 2017

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

7 April 2017

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

7 April 2017

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Weight-reducing effects of the plasma protein encoded by the obese gene

7 April 2017

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Effects of the obese gene product on body weight regulation in ob/ob mice

7 April 2017

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Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus

7 April 2017

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Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists

27 September 2017

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Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

27 September 2017

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Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

27 September 2017

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Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

27 September 2017

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Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

27 September 2017

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Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus

27 September 2017

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The role of TNFalpha and TNF receptors in obesity and insulin resistance

27 September 2017

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Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

27 September 2017

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Unraveling the central nervous system pathways underlying responses to leptin

27 September 2017

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Regulation of fatty acid homeostasis in cells: novel role of leptin

27 September 2017

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Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

27 September 2017

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A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.

27 September 2017

1 reference

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TNF-alpha and insulin resistance: summary and future prospects

27 September 2017

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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

27 September 2017

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Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

27 September 2017

1 reference

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Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Regional adiposity and morbidity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Pathophysiology of insulin resistance in human disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Autonomic and endocrine factors in the regulation of food intake

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Amelioration of insulin resistance in streptozotocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Weight as a risk factor for clinical diabetes in women.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=380258

What’s in a Name? In Search of Leptin’s Physiologic Role1

28 November 2018

1 reference

12 December 2020

Dose-response curves for in vivo insulin sensitivity in individual tissues in rats

1 reference

12 December 2020

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

12 December 2020

High-Fat Feeding Impairs Insulin-Stimulated GLUT4 Recruitment via an Early Insulin-Signaling Defect

1 reference

12 December 2020

Obesity in the new millennium

1 reference

12 December 2020

The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action

1 reference

12 December 2020

Fat tissue: a steroid reservoir and site of steroid metabolism

1 reference

12 December 2020

Signaling mechanisms that regulate glucose transport

1 reference

12 December 2020

Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans

1 reference

12 December 2020

Acute stimulation of glucose metabolism in mice by leptin treatment

1 reference

12 December 2020

Leptin Directly Alters Lipid Partitioning in Skeletal Muscle

1 reference

12 December 2020

CL-316,243, a beta3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats

1 reference

12 December 2020