O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients (Q24607903)

1

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Christine Pirker

2

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Martin Filipits

3

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Daniela Lötsch

4

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Johanna Buchroithner

5

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Josef Pichler

6

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Rene Silye

7

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Serge Weis

8

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Michael Micksche

9

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Johannes Fischer

10

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Walter Berger

MGMT gene silencing and benefit from temozolomide in glioblastoma

11

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language of work or name

English

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publication date

January 2010

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published in

Neuro-Oncology

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volume

12

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issue

1

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page(s)

28-36

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cites work

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

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Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide

27 September 2017

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Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer

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Clinical relevance of MGMT in the treatment of cancer

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Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents

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O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.

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Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

27 September 2017

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Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells

27 September 2017

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O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines

27 September 2017

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Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas

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Methylguanine methyltransferase testing in glioblastoma: when and how?

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CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas

21 January 2018

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Correlation of clinical features and methylation status of MGMT gene promoter in glioblastomas

21 January 2018

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Correlation between promoter hypermethylation of the O6-methylguanine-deoxyribonucleic acid methyltransferase gene and prognosis in patients with high-grade astrocytic tumors treated with surgery, radiotherapy, and 1-(4-amino-2-methyl-5-pyrimidinyl)

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Prognostic significance of O6-methylguanine-DNA methyltransferase protein expression in patients with recurrent glioblastoma treated with temozolomide

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Promoter Hypermethylation of the DNA Repair Gene O6‐Methylguanine‐DNA Methyltransferase is an Independent Predictor of Shortened Progression Free Survival in Patients with Low‐grade Diffuse Astrocytomas

28 November 2018

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O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme

28 November 2018

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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

28 November 2018

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DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma

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Direct Correlation Between Methylation Status and Expression of the Human O-6-MethyIguanine DNA Methyltransferase Gene

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12 December 2020

DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

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12 December 2020

Integrin inhibitors reaching the clinic

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12 December 2020

Intratumoral homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas

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12 December 2020

MGMT immunohistochemical expression and promoter methylation in human glioblastoma

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12 December 2020