Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer (Q34288659)

1 August 2017

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title

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer (English)

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1 August 2017

1

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1 August 2017

2

James G Herman

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PubMed ID

14712205

1 August 2017

language of work or name

English

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publication date

1 January 2004

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1 August 2017

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1 August 2017

23

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1 August 2017

1

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1 August 2017

1-8

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207316

1 August 2017

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Next-nucleotide effects in mutations driven by DNA precursor pool imbalances at the aprt locus of Chinese hamster ovary cells

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5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

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Novel genetic polymorphisms in DNA repair genes: O(6)-methylguanine-DNA methyltransferase (MGMT) and N-methylpurine-DNA glycosylase (MPG) in lung cancer patients from Poland.

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DNA repair gene O6-methylguanine-DNA methyltransferase: promoter hypermethylation associated with decreased expression and G:C to A:T mutations of p53 in brain tumors

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The impact of chromatin in human cancer: linking DNA methylation to gene silencing

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7 January 2021

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7 January 2021

Exposure of humans to endogenous N-nitroso compounds: implications in cancer etiology

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7 January 2021

Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone

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O6-methylguanine inhibits the binding of transcription factors to DNA.

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O6-methylguanine in DNA inhibits replication in vitro by human cell extracts

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Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

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7 January 2021

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase

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Novel O6-methylguanine-DNA methyltransferase SNPs: a frequency comparison of patients with familial melanoma and healthy individuals in Sweden

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7 January 2021

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

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7 January 2021

Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes

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7 January 2021

CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future

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7 January 2021

hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis

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7 January 2021

Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

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Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

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7 January 2021

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

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The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties

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DNA methylation: a profile of methods and applications

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7 January 2021

Regulatory issues in the evaluation of antimetastatic and other novel anticancer therapies

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7 January 2021

Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues.

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7 January 2021

Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

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7 January 2021

Inactivation of O6-methylguanine-DNA methyltransferase in human lung adenocarcinoma relates to high-grade histology and worse prognosis among smokers.

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7 January 2021

A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers

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7 January 2021

Molecular epidemiology of human cancer

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7 January 2021

A polymorphism at codon 160 of human O6-methylguanine-DNA methyltransferase gene in young patients with adult type cancers and functional assay

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7 January 2021

Characterization of human polymorphic DNA repair methyltransferase.

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7 January 2021

A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice

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7 January 2021

Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.

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7 January 2021

The role of mRNA stability and transcription in O6-methylguanine DNA methyltransferase (MGMT) expression in Mer+ human tumor cells

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7 January 2021

Instability and decay of the primary structure of DNA

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7 January 2021

Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma

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7 January 2021

Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.

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7 January 2021

DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal

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7 January 2021

O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts

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7 January 2021

Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Aberrant silencing of the CpG island-containing human O6-methylguanine DNA methyltransferase gene is associated with the loss of nucleosome-like positioning

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

p53 mutational spectra and the role of methylated CpG sequences

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Comparison of O-6-methylguanine DNA methyltransferase (MGMT) mRNA levels in Mer+ and Mer- human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Endogenous N-nitrosation in man assessed by measurement of apparent total N-nitroso compounds in faeces

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Mutations of O6-methylguanine-DNA methyltransferase gene in esophageal cancer tissues from Northern China.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Influence of dietary protein and gut microflora on endogenous synthesis of nitrate and N-nitrosamines in the rat.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Pharmacogenomics--teaching old drugs new tricks.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Chinese hamster cells harbouring the Escherichia coli O6-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207316

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207316

1 reference

PubMed ID

14712205

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

14712205