Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated (Q24608897)

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English	Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated	scientific article

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scholarly article

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Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated (English)

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rheumatoid arthritis

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based on heuristic

inferred from title

object named as

A Davidson

6

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Vincent R Bonagura

object named as

V Bonagura

5

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author name string

K Youngblood

1

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L Fruchter

2

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G Ding

3

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J Lopez

4

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language of work or name

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publication date

February 1994

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Journal of Clinical Investigation

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93

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2

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852-61

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Immunoglobulin genes of different subgroups are interdigitated within the VK locus

1 reference

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7 April 2017

Organization of human immunoglobulin heavy chain diversity gene loci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

7 April 2017

A fetally expressed immunoglobulin VH1 gene belongs to a complex set of alleles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

B lymphocytes, B cell clones and rheumatoid factor antibodies in rheumatoid inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Rheumatoid factors in immune complexes of patients with rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Idiotypic and molecular characterization of human rheumatoid factors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidenc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

The biologic significance of human natural autoimmune responses: relationship to the germline, early immune and malignant B cell variable gene repertoire

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

The rheumatoid factor reactivity of a human IgG monoclonal autoantibody is encoded by a variant V kappa II L chain gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Human immunoglobulin heavy-chain variable region genes: organization, polymorphism, and expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Complete sequence of the genes encoding the VH and VL regions of low- and high- affinity monoclonal lgM and lgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Generation and analysis of clonal IgM- and IgG-producing human B cell lines expressing an anti-DNA-associated idiotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

The immunoglobulin kappa light chain repertoire expressed in the synovium of a patient with rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Evidence for somatic selection of natural autoantibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

A human systemic lupus erythematosus-related anti-cardiolipin/single-stranded DNA autoantibody is encoded by a somatically mutated variant of the developmentally restricted 51P1 VH gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Immunoglobulin V genes in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

Monoclonal IgM rheumatoid factors bind IgG at a discontinuous epitope comprised of amino acid loops from heavy-chain constant-region domains 2 and 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

27 September 2017

The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

30 May 2018

Early restriction of the human antibody repertoire.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

30 May 2018

Expression of three cross-reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

30 May 2018

Structural characterization of the second major cross-reactive idiotype group of human rheumatoid factors. Association with the VH4 gene family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

30 May 2018

The V kappa gene repertoire in the human germ line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

30 May 2018

Molecular analysis of V kappa III variable regions of polyclonal rheumatoid factors during rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

30 May 2018

Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

30 May 2018

Monoclonal antibody 6b6.6 defines a cross-reactive kappa light chain idiotope on human monoclonal and polyclonal rheumatoid factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

30 May 2018

Molecular analysis of the V kappa III-J kappa junctional diversity of polyclonal rheumatoid factors during rheumatoid arthritis frequently reveals N addition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

30 May 2018

A rheumatoid factor from a normal individual encoded by VH2 and V kappa II gene segments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

30 May 2018

Molecular analysis of rheumatoid factors derived from rheumatoid synovium suggests an antigen-driven response in inflamed joints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

28 November 2018

A monoclonal anti-idiotype specific for human polyclonal IgM rheumatoid factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293948

28 November 2018

Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/7509350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutations in the VH genes of high-affinity antibodies to self and foreign antigens produced by human CD5+ and CD5- B lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7509350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restricted immunoglobulin variable region gene usage by hybridoma rheumatoid factors from patients with systemic lupus erythematosus and rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7509350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping studies reveal unique epitopes on IgG recognized by rheumatoid arthritis-derived monoclonal rheumatoid factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7509350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheumatoid factors and secondary immune responses in the mouse. I. Frequent occurrence of hybridomas secreting IgM anti-IgG1 autoantibodies after immunization with protein antigens

1 reference

https://pubmed.ncbi.nlm.nih.gov/7509350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheumatoid factors and secondary immune responses in the mouse. II. Incidence, kinetics and induction mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/7509350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drastic change in idiotypic but not antigen-binding specificity of an antibody by a single amino-acid substitution

1 reference

https://pubmed.ncbi.nlm.nih.gov/7509350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheumatoid factor and immune networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/7509350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incidence of three cross-reactive idiotypes on human rheumatoid factor paraproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/7509350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheumatoid factor autoantibody-binding site: a molecular analysis using monoclonal antibodies with dual anti-TNP and anti-IgG activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/7509350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation of expression of two rheumatoid factor cross-reactive kappa L chain idiotopes in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7509350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1172/JCI117040

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