Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response (Q36231063)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1740665%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

title

Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response (English)

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17 September 2019

4

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17 September 2019

author name string

T Olee

1

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17 September 2019

E W Lu

2

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17 September 2019

D F Huang

3

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17 September 2019

M Deftos

5

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17 September 2019

F Kozin

6

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17 September 2019

D A Carson

7

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17 September 2019

P P Chen

8

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17 September 2019

language of work or name

English

0 references

publication date

1 March 1992

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Journal of Experimental Medicine

17 September 2019

published in

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17 September 2019

volume

175

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17 September 2019

issue

3

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17 September 2019

page(s)

831-842

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Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes

17 September 2019

cites work

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Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments

1 October 2017

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A comprehensive set of sequence analysis programs for the VAX

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Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region

1 October 2017

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1 October 2017

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Evolution of human immunoglobulin kappa J region genes

1 October 2017

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1 October 2017

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The immunopathology of joint inflammation in rheumatoid arthritis

1 October 2017

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1 October 2017

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Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus

1 October 2017

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The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1 October 2017

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Mutation drift and repertoire shift in the maturation of the immune response

1 October 2017

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Evolution of antibody variable region structure during the immune response

1 October 2017

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Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis

1 October 2017

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Stepwise intraclonal maturation of antibody affinity through somatic hypermutation

1 October 2017

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Organization of human immunoglobulin heavy chain diversity gene loci

1 October 2017

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Cross-reacting idiotypes on cryoprecipitating rheumatoid factor

1 October 2017

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Developmentally regulated and strain-specific expression of murine VH gene families

1 October 2017

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Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes

1 October 2017

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Isolation and characterization of a light chain variable region gene for human rheumatoid factors

1 October 2017

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Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity

1 October 2017

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Human lambda light chain locus: organization and DNA sequences of three genomic J regions

1 October 2017

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Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes

1 October 2017

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Rheumatoid factors in immune complexes of patients with rheumatoid arthritis

1 October 2017

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V genes encoding autoantibodies: molecular and phenotypic characteristics

1 October 2017

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Dispersed localization of D segments in the human immunoglobulin heavy-chain locus

1 October 2017

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Beyond clonal selection and network

1 October 2017

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The role of somatic hypermutation in the generation of antibody diversity

1 October 2017

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The smaller human VH gene families display remarkably little polymorphism

1 October 2017

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A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation

1 October 2017

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Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene

1 October 2017

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Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia

1 October 2017

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First genomic sequence of a human Ig variable lambda gene belonging to subgroup I. Functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus.

1 October 2017

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Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response

1 October 2017

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Characterization of four homologous L chain variable region genes that are related to 6B6.6 idiotype positive human rheumatoid factor L chains

1 October 2017

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Probing the human B-cell repertoire with EBV: polyreactive antibodies and CD5+ B lymphocytes

1 October 2017

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Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1 October 2017

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Rheumatoid arthritis. Pathophysiology and implications for therapy

1 October 2017

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The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidenc

1 October 2017

1 reference

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In vitro autoantibody production by normal adult and cord blood B cells

1 October 2017

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The biologic significance of human natural autoimmune responses: relationship to the germline, early immune and malignant B cell variable gene repertoire

1 October 2017

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From human autoantibodies to the fetal antibody repertoire to B cell malignancy: it's a small world after all.

1 October 2017

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Autoantibodies and the fetal antibody repertoire

1 October 2017

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Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life

1 October 2017

1 reference

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The early expression of some human autoantibody-associated heavy chain variable region genes is controlled by specific regulatory elements

1 October 2017

1 reference

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Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation

1 October 2017

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Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes

1 October 2017

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New roles for rheumatoid factor

1 October 2017

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Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions.

1 October 2017

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VH genes of human autoantibodies

1 October 2017

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Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases

1 October 2017

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DNA sequencing with chain-terminating inhibitors

1 October 2017

1 reference

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Characterization of IgG complexes in eluates from rheumatoid tissue

1 October 2017

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A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation

29 June 2018

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The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus

29 June 2018

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Early restriction of the human antibody repertoire

29 June 2018

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Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families.

29 June 2018

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Characterization of two immunoglobulin VH genes that are homologous to human rheumatoid factors

29 June 2018

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Polymerase chain reaction with single-sided specificity: analysis of T cell receptor delta chain

29 June 2018

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The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutations

29 June 2018

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Serologic and molecular characterization of a human monoclonal rheumatoid factor derived from rheumatoid synovial cells.

29 June 2018

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Structural analyses of human developmentally regulated Vh3 genes.

29 June 2018

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A segment of human Vh gene locus is duplicated

29 June 2018

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Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus

29 June 2018

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Antibody specificity and immunoglobulin VH utilization of human monoclonal CD5+ B cell lines

29 June 2018

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The role of clonal selection and somatic mutation in autoimmunity

29 June 2018

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12 December 2020

Gamma globulin complexes in synovial fluids of patients with rheumatoid arthritis. Partial characterization and relationship to lowered complement levels

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12 December 2020

High connectivity, natural antibodies preferentially use 7183 and QUPC 52 VH families

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12 December 2020

Generation and Characterization of two Monoclonal Self-Associating IgG Rheumatoid Factors from a Rheumatoid Synovium

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12 December 2020

Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization

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12 December 2020

Restricted diversity of the variable region nucleotide sequences of the heavy and light chains of a human rheumatoid factor

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12 December 2020

Rheumatoid factor and immune networks

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12 December 2020

Structural and idiotypic characterization of the L chains of human IgM autoantibodies with different specificities

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12 December 2020

Preferential expression of VH5 and VH6 immunoglobulin genes in early human B-cell ontogeny

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12 December 2020

The human VK locus. Characterization of a duplicated region encoding 28 different immunoglobulin genes

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12 December 2020

Identifiers

DOI

10.1084/JEM.175.3.831

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1740665%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1740665%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

PubMed publication ID

1740665

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1740665%20AND%20SRC:MED&resulttype=core&format=json